DB04987ExperimentalProtein Based Therapies
P-113D is a novel 12 amino-acid antimicrobial peptide drug derived from histatins, which are compounds found naturally in human saliva. It is being pursued as a potential treatment for cystic...
- Mechanism
- Curator reviewed
For both bacteria and fungi such as Candida albicans, P-113D has been shown to kill cells as opposed to simply inhibiting their growth. It has been demonstrated that P-113D acts by binding to the cell surface and increasing the permeability of both the outer and inner membranes of the cells of Gram negative bacteria, killing them within seconds.
- Primary indication
- For the potential treatment of cystic fibrosis and bacterial infections.Curator reviewed
- Also known as
- D-PEPTIDE OF THE SEQUENCE AKRHHGYKRKFH - NH2 ยท Pulmadex
- Code names
- P-113D
Resolves to
Compound
Which companies are running trials of P-113D, in which indications and phases, and which of those programs are still active?
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