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Mestranol
go.drugbank.com/drugs/DB01357ApprovedWithdrawnThe 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 SubstratesPenbutolol
go.drugbank.com/drugs/DB01359ApprovedInvestigationalWithdrawnPenbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergi...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesParamethasone
go.drugbank.com/drugs/DB01384ExperimentalA glucocorticoid with the general properties of corticosteroids. It has been used by mouth in the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-reta...
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 SubstratesYohimbine
go.drugbank.com/drugs/DB01392ApprovedInvestigationalVet approvedWithdrawnA plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.
Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsDrospirenone
go.drugbank.com/drugs/DB01395ApprovedInvestigationalDrospirenone is a synthetic progestin commonly found in the popular oral contraceptive, Yaz in combination with Ethinyl estradiol. Most recently, it was approved by both Health Canada and the FDA in combination with Estetrol as an oral c...
Mixtures: ETINILESTRADIOLO E DROSPIRENONE DOC GENERICI, ETINILESTRADIOLO E DROSPIRENONE DOC GENERICICategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesDanazol
go.drugbank.com/drugs/DB01406ApprovedInvestigationalA synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used i...
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 Inhibitors5-Methoxy-N,N-diisopropyltryptamine
go.drugbank.com/drugs/DB01441ExperimentalIllicit5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) is a tryptamine derivative and shares many similarities with schedule I tryptamine hallucinogens such as alpha-ethyltryptamine, N,N-dimethyltryptamine, N,N-diethyltryptamine, bufotenine, p...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesBarbital
go.drugbank.com/drugs/DB01483ExperimentalIllicitA long-acting barbiturate that depresses most metabolic processes at high doses. It is used as a hypnotic and sedative and may induce dependence. Barbital is also used in veterinary practice for central nervous system depression. Barbita...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersAndrostenedione
go.drugbank.com/drugs/DB01536IllicitInvestigationalA delta-4 C19 steroid that is produced not only in the testis, but also in the ovary and the adrenal cortex. Depending on the tissue type, androstenedione can serve as a precursor to testosterone as well as estrone and estradiol.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesFlunitrazepam
go.drugbank.com/drugs/DB01544ApprovedIllicitFlunitrazepam is a benzodiazepine with pharmacologic actions similar to those of diazepam that can cause anterograde amnesia. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior....
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 Substrates