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Eteplirsen
go.drugbank.com/drugs/DB06014ApprovedInvestigational[A244930] It is caused by loss-of-function mutations in the DMD gene coding for dystrophin, an essential protein involved in maintaining the structural integrity and function of muscle fibres. … It consists of a six-membered morpholino ring replacing the five-membered ribofuranosyl rings found in natural DNA and RNA.
Categories: Nucleic Acids, Nucleotides, and Nucleosides, Compounds used in a research, industrial, or household settingSynonyms: N-dimethylphosphonamidate) RNA, dimethylamino)](2',3'-dideoxy-2',3'-imino-2',3'-seco)(2'a→5')(C-m5U-C-C-A-A-C-A-m5U-C-A-A-G-G-A-A-G-A-m5U-G-G-C-A-m5U-m5U-m5U-C-m5U-A-G),5'-(P-(4-((2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)carbonyl)-1-piperazinyl)-N,Butalbital
go.drugbank.com/drugs/DB00241ApprovedIllicitButalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. … [L10370] Butalbital‐containing analgesics can also produce a drug‐induced headache in addition to tolerance and dependence.
Synonyms: 5-allyl-5-(2'-methyl-n-propyl) barbituric acidMixtures: Butalbital, Aspirin, and Caffeine, Butalbital, Aspirin and CaffeineIdebenone
go.drugbank.com/drugs/DB09081ApprovedInvestigationalIt is not currently approved for use by either the Food and Drug Administration (USA) or Health Canada. … Due to its biochemical mode of action, it's thought that idebenone may re-activate viable-but-inactive retinal ganglion cells (RGCs) in LHON patients [L885].
Categories: Compounds used in a research, industrial, or household setting, Enzymes and CoenzymesOsteolytic lesion
go.drugbank.com/conditions/DBCOND0020866Drugs: Pamidronic acidSynonyms: (Other and unspecified bone or cartilage disorders) or (osteolytic lesion)Cutaneous lesions
go.drugbank.com/conditions/DBCOND0021486Synonyms: (Other skin and subcut tissue disease NOS) or (skin lesion)Collagenase clostridium histolyticum
go.drugbank.com/drugs/DB00048ApprovedInvestigationalCollagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum. … It is beneficial in the breakdown of collagen plaques for the treatment of Dupuytren's contracture and Peyronie's disease.
Categories: Enzymes and Coenzymes, Skin and Mucous Membrane AgentsRilzabrutinib
go.drugbank.com/drugs/DB17709ApprovedInvestigational[L53743] ITP is an autoimmune disorder characterized by low platelet count. … Rilzabrutinib is an oral, reversible, covalent inhibitor of Bruton's tyrosine kinase [A259078, L53738] that was approved by the FDA on August 29, 2025, for the treatment of persistent and chronic immune
Technetium Tc-99m disofenin
go.drugbank.com/drugs/DB09164ApprovedWithdrawnIt is available as an intravenous injection in a preparation kit under the name Hepatolite. … It is well suited for both planar and single photon tomographic scintigraphy to quantitatively measure the function of liver, gallbladder and bile ducts and detect any anatomical changes in the hepatobliary
Categories: Compounds used in a research, industrial, or household setting, Indicators and ReagentsIpecac
go.drugbank.com/drugs/DB13293ApprovedWithdrawn[L2753] Ipecac was approved by Health Canada as an OTC but all those products are now discontinued. … [L1113] The FDA does not have currently any approved product containing ipecac, however, ipecac as an ingredient is accepted to be sold over the counter in packages of 1 fluid ounce (30 ml) for the emergency
Categories: Cough and Cold PreparationsSamidorphan
go.drugbank.com/drugs/DB12543ApprovedInvestigational, and a longer half-life, making it an attractive candidate for oral dosing. … by Alkermes Inc.
Categories: olanzapine and samidorphan, Diazepines, Oxazepines, Thiazepines and Oxepines