Technetium Tc-99m disofenin is a radiopharmaceutical diagnostic agent used for hepatobiliary scans. It is well suited for both planar and single photon tomographic scintigraphy to quantitatively measure the function of liver, gallbladder and bile ducts and detect any anatomical changes in the hepatobliary system.
- Mechanism
- Curator reviewed · 1 reference
Gallbladder visualization and visualization of intestinal activity occurs by 60 minutes post-injection in individuals with normal hepatobiliary function. Radiopharmaceutical agent is delivered to liver sinusoids via the portal vein and hepatic artery to diffuse through the pores in the endothelial lining to bind to a specific membrane bound carrier, which transports the tracer across the hepatocyte membrane and into the hepatocyte. Once inside the hepatocyte, the tracer may be bound by various enzymes and/or undergo metabolism.
- Primary indication
- Technetium Tc99m Disofenin is indicated as a hepatobiliary imaging agent.Curator reviewed · 2 structured indications
- Formula / weight
- C18H26N2O5Tc · 449.321 g/mol (avg)
- First approval
- United States, 1982
- Also known as
- 99mTc-DISIDA · 99mTc-Disofenin · Technetium (99mTc) disofenin · Technetium Tc 99m Disofenin · Technetium-99m-Diisopropyliminodiacetic Acid
Resolves to
JNJYQGLIZTUSCW-NLQOEHMXSA-NSMILES[99Tc].CC(C)C1=CC=CC(C(C)C)=C1NC(=O)CN(CC(O)=O)CC(O)=OWhat you can answer from here — as of April 02, 2025
Which other approved drugs treat the same conditions as Technetium Tc-99m disofenin, and which companies have late-stage candidates in those indications?
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