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Displaying results 2731 - 2740 of 10000 in total
  1. Drug

    Eflapegrastim

    go.drugbank.com/drugs/DB15001
    ApprovedInvestigational

    Febrile neutropenia (FN), defined as the co-occurrence of fever (temperature > 38 ◦C) and severe neutropenia (ANC < 500 cells/mm<sup>3</sup>), is a potential side effect of myelosuppressive chemotherapy … in which the patient develops an infection during a period of significant neutropenia.

  2. Drug

    Ipecac

    go.drugbank.com/drugs/DB13293
    ApprovedWithdrawn

    [L1113] The FDA does not have currently any approved product containing ipecac, however, ipecac as an ingredient is accepted to be sold over the counter in packages of 1 fluid ounce (30 ml) for the emergency … use to cause vomiting in poisoning.

    Categories: Complex Mixtures
  3. Drug

    Lumasiran

    go.drugbank.com/drugs/DB15935
    ApprovedInvestigational

    [L23554] Lumasiran was granted FDA approval on 23 November 2020.[L23394] … Lumasiran is a small interfering RNA used in the treatment of primary hyperoxaluria type 1 (PH1).

  4. Drug

    Influenza B virus B/Washington/02/2019 antigen (formaldehyde inactivated)

    go.drugbank.com/drugs/DB15620
    ApprovedInvestigational

    Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised individuals. … In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated, or weakened, through various laboratory techniques.

    Mixtures: Fluarix Quadrivalent 2020/2021, VaxigripTetra Injektionssuspension in einer Fertigspritze
  5. Target

    Leucine-rich repeat-containing G protein-coupled receptor 5

    go.drugbank.com/bio_entities/BE0010835
    TargetHumans

    Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with ph...

    Polypeptides: Leucine-rich repeat-containing G protein-coupled receptor 5
  6. Drug

    Streptococcus pneumoniae type 20A capsular polysaccharide diphtheria CRM197 protein conjugate antigen

    go.drugbank.com/drugs/DB19347
    ApprovedInvestigational

    The saccharides in the vaccine are prepared from purified polysaccharides that are chemically activated then conjugated to the protein carrier CRM197 to form the glycoconjugate. … _ serotype 20A individually conjugated to the CRM197 protein, a nontoxic variant of diphtheria toxin isolated from cultures of _Corynebacterium diphtheriae_ strain C7 (β197).

    Synonyms: Streptococcus pneumoniae type 20A capsular polysaccharide diphtheria CRM197 protein conjugate antigen
  7. Drug

    Florfenicol

    go.drugbank.com/drugs/DB11413
    ExperimentalVet approved

    Florfenicol is a fluorinated synthetic analog of thiamphenicol.

    Synonyms: D-threo-2,2-Dichloro-N-(alpha-(fluoromethyl)-beta-hydroxy-p-(methylsulfonyl)phenethyl)acetamideProducts: Florcol Oral Solution 250mg/ml
  8. Target

    Leucine-rich repeat serine/threonine-protein kinase 2

    go.drugbank.com/bio_entities/BE0009457
    TargetHumans

    Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:2185...

    Polypeptides: Leucine-rich repeat serine/threonine-protein kinase 2
  9. Target

    F-box-like/WD repeat-containing protein TBL1X

    go.drugbank.com/bio_entities/BE0012106
    TargetHumans

    F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units (PubMed:14980219). … Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes

    Polypeptides: F-box-like/WD repeat-containing protein TBL1X
  10. Drug

    Zavegepant

    go.drugbank.com/drugs/DB15688
    ApprovedInvestigational

    of oral zavegepant (150 mg bid) in subjects with mild allergic asthma. … [A258190,A258195] In March 2023, the FDA approved the use of zavegepant nasal spray for the acute treatment of migraine with or without aura in adults.

    Synonyms: 1-piperidinecarboxamide, 4-(1,2-dihydro-2-oxo-3-quinolinyl)-n-((1r)-1-((7-methyl-1h-indazol-5-yl)methyl)-2-(4-(1-methyl-4-piperidinyl)-1-piperazinyl)-2-oxoethyl)-