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Quazepam
go.drugbank.com/drugs/DB01589ApprovedIllicitQuazepam is a trifluoroethyl benzodiazepine derivative. It was first approved in the US in 1985 and is used as a hypnotic for the treatment of insomnia. It appears to be unique amongst other benzodiazepine derivatives in its relatively h...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InhibitorsLopinavir
go.drugbank.com/drugs/DB01601ApprovedInvestigationalLopinavir is an antiretroviral protease inhibitor used in combination with other antiretrovirals in the treatment of HIV-1 infection. Lopinavir is marketed and administered exclusively in combination with ritonavir - this combination, fi...
Categories: P-glycoprotein inducers, P-glycoprotein inhibitorsBacampicillin
go.drugbank.com/drugs/DB01602ApprovedWithdrawnBacampicillin is a prodrug of ampicillin and is microbiologically inactive. It is absorbed following oral administration. During absorption from the gastrointestinal tract, bacampicillin is hydrolyzed by esterases present in the intestin...
Deferasirox
go.drugbank.com/drugs/DB01609ApprovedInvestigationalDeferasirox is an iron chelator and the first oral medication FDA approved for chronic iron overload in patients receiving long term blood transfusions.
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP1A2 Inhibitors8-azaguanine
go.drugbank.com/drugs/DB01667Experimental8-azaguanine is one of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesDalfopristin
go.drugbank.com/drugs/DB01764ApprovedDalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections. Da...
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsN,N-dimethylformamide
go.drugbank.com/drugs/DB01844ExperimentalCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2E1 SubstratesEquilin
go.drugbank.com/drugs/DB02187ExperimentalAn estrogenic steroid produced by horses. It has a total of four double bonds in the A- and B-ring. High concentration of equilin is found in the urine of pregnant mares.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesDitiocarb
go.drugbank.com/drugs/DB02520InvestigationalA chelating agent that has been used to mobilize toxic metals from the tissues of man and experimental animals. It is the main metabolite of DISULFIRAM.
Categories: Cytochrome P-450 CYP2A6 Inhibitors, Cytochrome P-450 CYP3A Inhibitors