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Levetiracetam
go.drugbank.com/drugs/DB01202ApprovedInvestigationalmake it a desirable choice over other AEDs, a class of drugs notorious for having generally narrow therapeutic indexes and a propensity for involvement in drug interactions. … It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs).
Categories: P-glycoprotein substrates, Heterocyclic Compounds, 1-RingProducts: Levetiracetam in Sodium Chloride, LEVEBRAIN 500 MG / 5 ML KONSANTRE INF. ÇÖZELTISI IÇEREN FLAKON, FLAKON, 1 ADETIsosorbide dinitrate
go.drugbank.com/drugs/DB00883ApprovedInvestigationalA vasodilator used in the treatment of angina pectoris. Its actions are similar to nitroglycerin but with a slower onset of action.
Synonyms: D-Isosorbide dinitrateCategories: Vasodilators Used in Cardiac Diseases, Cytochrome P-450 CYP2E1 InhibitorsEptifibatide
go.drugbank.com/drugs/DB00063ApprovedInvestigationalDerived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics.
Products: INTEGRILIN IV BOLUS INJECTION 2 mg/ml, EPTICARD 20 MG/10 ML IV ENJEKSİYONLUK ÇÖZELTİ İÇEREN FLAKON, 1 ADETAxitinib
go.drugbank.com/drugs/DB06626ApprovedInvestigational[A179398] It is most commonly marketed under the name Inlyta® and is available in oral formulations. … It is reported to exhibit potency that is 50-450 times higher than that of the first generation VEGFR inhibitors.[L6676] Axitinib is an indazole derivative.
Synonyms: N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamideCategories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexSarilumab
go.drugbank.com/drugs/DB11767ApprovedInvestigationalcascades of IL-6. … Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersProducts: KEVZARA SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 150MG, KEVZARA Solution for Injection in Pre-filled Pen 150mgEpinastine
go.drugbank.com/drugs/DB00751ApprovedIt has a multi-action effect that inhibits the allergic response in 3 ways: 1. stabilizes mast cells by preventing mast cell degranulation to control the allergic response, 2. prevents histamine binding … Epinastine is used for the prevention of itching associated with allergic conjunctivitis.
Synonyms: 3-amino-9,13b-dihydro-1H-dibenz(c,f)imidazo(1,5-a)azepineMixtures: FLURINOL(R) D COMPRIMIDOS DE LIBERACION MODIFICADAFluticasone propionate
go.drugbank.com/drugs/DB00588ApprovedInvestigationalFluticasone propionate is a synthetic glucocorticoid[F4355,F4358][FDA Label]. … Fluticasone propionate was first approved in 1990[L5962].
Mixtures: FLUTIFORM® 50 MCG / 5 MCG, FLUTIFORM® 50 MCG / 5 MCGCategories: P-glycoprotein substrates, Cytochrome P-450 SubstratesBusulfan
go.drugbank.com/drugs/DB01008ApprovedInvestigationalBusulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. … It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 SubstratesSynonyms: 1, 4-Bis[methanesulfonoxy]butaneBenmelstobart
go.drugbank.com/drugs/DB17473InvestigationalAPL 502 is a humanised immunoglobulin G1 (IgG1) monoclonal antibody targeting the programmed cell death-1 ligand-1 (PD-L1).
Synonyms: gamma1 heavy chain humanized (1-446) [VH (Homo sapiens IGHV2-5*01 (78.6%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.7.10] (26-33.51-57.96-105)) (1-116)-Homo sapiens IGHG1*01, G1m17,1 CH1 K120, CH3 D12, L14, 贝莫苏拜单抗Diphenhydramine
go.drugbank.com/drugs/DB01075ApprovedInvestigationalDiphenhydramine has also been shown to be implicated in a number of neurotransmitter systems that affect behaviour including dopamine, norepinephrine, serotonin, acetylcholine, and opioid [A1539]. … As a result, diphenhydramine is being investigated for its anxiolytic and anti-depressant properties.
Synonyms: N-(2-(diphenylmethoxy)ethyl)-N,N-dimethylamine, 2-(benzhydryloxy)-N,N-dimethylethylamineInternational brands: Dormarex 2