Fluticasone propionate is a glucocorticoid used to treat asthma, inflammatory pruritic dermatoses, and nonallergic rhinitis. These drugs are available as inhalers, nasal, sprays, and topical treatments for various inflammatory indications.
- Mechanism
- Curator reviewed · 3 references
Fluticasone propionate works through an unknown mechanism to affect the action of various cell types and mediators of inflammation. Fluticasone propionate activates glucocorticoid receptors and inhibits lung eosinophilia in rats.
- Primary indication
- Fluticasone propionate is indicated as an inhaler for the treatment and management of asthma by prophylaxisas well as inflammatory and pruritic dermatoses.Curator reviewed · 31 structured indications
- Formula / weight
- C25H31F3O5S · 500.571 g/mol (avg)
- First approval
- Canada, 2001 · United States, 1990 · European Union, 2021
- Code names
- CCI-18781 · PF-00241939
- Brand names
Resolves to
Clinical / RWD
Structure
InChIKey
WMWTYOKRWGGJOA-CENSZEJFSA-NSMILES[H][C@@]12C[C@@H](C)[C@](OC(=O)CC)(C(=O)SCF)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12CTransporters
What you can answer from here — as of September 23, 2026
4Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
2TransportersSubstrate / inhibitor direction, not just membershipListed above
Which drugs share a target with Fluticasone propionate, and which of those have an active Phase 3 trial?
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