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Calcitriol
go.drugbank.com/drugs/DB00136ApprovedInvestigationalNutraceuticalCalcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred to as 1,25-dihydroxycholecalciferol, or 1alpha,25-dihydroxyvitamin D<sub>3</sub>, 1,25-dihydroxyvitamin … [DB00146] undergoes hydroxylation to form calcitriol via 1α-hydroxylase (CYP27B1) activity [A26353]. Calcitriol is considered to be the most potent metabolite of vitamin D in humans [A3366].
Categories: Vitamin D and Analogues, Cytochrome P-450 SubstratesSynonyms: 1α,25(OH)2D3, 1-alpha-25-Dihydroxyvitamin D3Saxagliptin
go.drugbank.com/drugs/DB06335ApprovedInvestigationalSaxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009.
Mixtures: QTERN 5 MG/10 MG FİLM KAPLI TABLET, 28 ADET, Qtern 5 mg/10 mg Film-Coated TabletsCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesIMT-288
go.drugbank.com/drugs/DB19068InvestigationalIMT-288 is under investigation in clinical trial NCT01730638 (Immunotep for Patients With Medullary Thyroid Carcinoma.).
Synonyms: (4R)-5-(((1R)-1-CARBAMOYL-5-((2-((4-(2-(1H-IMIDAZOL-5-YL)ETHYLAMINO)-4-OXO-BUTANOYL)AMINO)ACETYL)AMINO)PENTYL)AMINO)-4-(((2R)-2-(((2R)-3-(4-HYDROXYPHENYL)-2-((2-(4,7,10-TRIS(CARBOXYMETHYL)-1,4,7,10-TETRAZACYCLODODEC, -GLUTAMYL-N6-(N-(4-((2-(1H-IMIDAZOL-4-YL)ETHYL)AMINO)-1,4-DIOXOBUTYL)GLYCYApremilast
go.drugbank.com/drugs/DB05676ApprovedInvestigationalIt belongs to the same drug class as [Roflumilast] and [Crisaborole].[A181244,L7495] Initially approved in 2014, it is marketed by Celgene. … Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases.
Synonyms: N-{2-[(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamideMixtures: OTEZLA 10 MG. 20 MG Y 30 MG, OTEZLA 10 MG. 20 MG Y 30 MGNaloxone
go.drugbank.com/drugs/DB01183ApprovedInvestigationalVet approved[L33714,L33719] Naloxone was granted FDA approval on 13 April 1971.[L33709] … Notably, if injected into a person not currently using opioid medications, there would be no noticeable effects at all.
Mixtures: Targin 10 mg/5 mg Retardtabletten, Oxylanox 10 mg/5 mg-RetardtablettenCategories: P-glycoprotein substrates, Cytochrome P-450 SubstratesPipotiazine
go.drugbank.com/drugs/DB01621ApprovedInvestigationalWithdrawnHowever, it produces a high incidence of extra pyramidal reactions. It is used for the maintenance treatment of chronic non-agitated schizophrenic patients. … Among the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics.
Categories: Serotonin 5-HT1 Receptor Antagonists, Serotonin 5-HT2 Receptor AntagonistsProducts: PIPORTIL ® L-4SOLUCION INYECTABLE AL 2.5% (100 MG)., TRIPIPOT® SOLUCIÓN INYECTABLE 25 MG/MLBetaxolol
go.drugbank.com/drugs/DB00195ApprovedInvestigationalA cardioselective beta-1-adrenergic antagonist with no partial agonist activity.
Categories: Adrenergic beta-1 Receptor Antagonists, Cytochrome P-450 SubstratesSynonyms: 1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-((1-methylethyl)amino)-2-propanol, 1-(isopropylamino)-3-[p-(cyclopropylmethoxyethyl)phenoxy]-2-propanolMacitentan
go.drugbank.com/drugs/DB08932ApprovedInvestigationalMacitentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension (PAH).[L35890] It was first approved by the FDA in 2013. … A combination product (Opsynvi) comprising macitentan and [tadalafil] was approved in Canada in October 2021 for the treatment of PAH.[L39105] It was subsequently approved by the FDA in March 2024.
Mixtures: OPSYNVI® (MACITENTAN/TADALAFILO) 10MG/40 MG TABLETAS RECUBIERTASCategories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 SubstratesTretinoin
go.drugbank.com/drugs/DB00755ApprovedInvestigationalNutraceutical[A257689] In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. … [A257474] It is an oxidation product in the physiological pathway of vitamin A metabolism.
Synonyms: Tretin M, (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acidInternational brands: Stieva-ACidofovir
go.drugbank.com/drugs/DB00369ApprovedInvestigationalIt suppresses CMV replication through selective inhibition of viral DNA synthesis. … [FDA label] It was manufactured by _Gilead_ and initially approved by the FDA in 1996, but has since been discontinued.[L6223]
Synonyms: (S)-(3-(4-amino-2-Oxopyrimidin-1(2H)-yl)-1-hydroxypropan-2-yloxy)methylphosphonic acid, [(S)-2-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-1-hydroxymethyl-ethoxymethyl]-phosphonic acidCategories: Heterocyclic Compounds, 1-Ring