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Nefazodone
go.drugbank.com/drugs/DB01149ApprovedWithdrawnOn May 20, 2004, Bristol-Myers Squibb discontinued the sale of Serzone in the United States. … Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury.
Ensartinib
go.drugbank.com/drugs/DB14860ApprovedInvestigational[A265030] The drug is 10-fold more potent in the inhibition of the growth of ALK-positive lung cancer cell lines when compared to [crizotinib]. … ALK-inhibitor on December 18, 2024.
Cyclin-dependent kinase 8
go.drugbank.com/bio_entities/BE0002224TargetHumansPhosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression (PubMed:10993082). … Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes.
Synonyms: Mediator complex subunit CDK8Proteasome subunit alpha type-4
go.drugbank.com/bio_entities/BE0003913TargetHumansComponent of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. … This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)
Synonyms: Multicatalytic endopeptidase complex subunit C9Atypical kinase COQ8A, mitochondrial
go.drugbank.com/bio_entities/BE0009381TargetHumansAtypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:21296186, PubMed:25498144, PubMed:25540914, PubMed:27499294, PubM...
Synonyms: Chaperone activity of bc1 complex-likeQuazepam
go.drugbank.com/drugs/DB01589ApprovedIllicitIt was first approved in the US in 1985 and is used as a hypnotic for the treatment of insomnia. … [L44913] It appears to be unique amongst other benzodiazepine derivatives in its relatively high affinity for sleep-promoting α1 subunit-containing GABA<sub>A</sub> receptors and low affinity for other
Fedratinib
go.drugbank.com/drugs/DB12500ApprovedInvestigational[A183176,L8090] It is an anilinopyrimidine derivative.[A183188] Fedratinib was granted FDA approval on August 16, 2019.[L8090]
Calcifediol
go.drugbank.com/drugs/DB00146ApprovedInvestigationalNutraceuticalIt is produced in the liver and is the best indicator of the body's vitamin D stores. It is effective in the treatment of rickets and osteomalacia, both in azotemic and non-azotemic patients.
Raxibacumab
go.drugbank.com/drugs/DB08902ApprovedInvestigationalRaxibacumab is produced by recombinant DNA technology in a murine cell expression system. FDA approved on December 14, 2012.
Nitric Oxide
go.drugbank.com/drugs/DB00435ApprovedInvestigationalThis gas is an important signaling molecule in the body of mammals including humans and is an extremely important intermediate in the chemical industry. … It reacts with the ozone in air to form nitrogen dioxide, signalled by the appearance of the reddish-brown color.
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