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Temozolomide
go.drugbank.com/drugs/DB00853ApprovedInvestigational[A229853, A229923] Temozomolide as an adjunct to radiotherapy followed by maintenance dosing remains the standard of care for both Glioblastoma and refractory anaplastic astrocytoma. … Despite considerable genetic heterogeneity, these tumours often have impaired DNA repair systems, rendering them initially sensitive to alkylating agents, although they invariably develop resistance to
Products: GLIOTEM 100 CAPSULE 100 MG, TEMOMID 100 MG KAPSUL, 5 ADETMycophenolic acid
go.drugbank.com/drugs/DB01024ApprovedInvestigational[A249180,A249185] Mycophenolic acid is available as enteric-coated tablets of delayed-release, in an effort to improve upper gastrointestinal adverse events by delaying mycophenolic acid release until … [A249190] [Mycophenolate mofetil], a prodrug of mycophenolic acid, is also prescribed to transplant recipients to prevent organ rejection.[L42020]
Synonyms: (e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acidCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 SubstratesDurvalumab
go.drugbank.com/drugs/DB11714ApprovedInvestigational[A192789] Produced by recombinant DNA technology in Chinese Hamster Ovary (CHO) cell suspension culture,[L12621] durvalumab is a programmed death-ligand 1 (PD-L1) blocking antibody that works to promote … ≥ 1% of tumour cells and there was no observable disease progression following platinum-based chemoradiation therapy.
Products: IMFINZI 500 MG/10 ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 ADET, IMFINZI 120 MG/2.4 ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 ADETDidanosine
go.drugbank.com/drugs/DB00900ApprovedInvestigationalDidanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative … A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen.
Synonyms: 9-((2R,5S)-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-1H-purin-6(9H)-one, 9-((2S,5R)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-olProducts: VIDEN TABLETAS MASTICABLES 10 MG, DIDANOSINA TABLETAS MASTICABLES 10 MGTrimebutine
go.drugbank.com/drugs/DB09089ApprovedInvestigationalIt is used to restore normal bowel function and is commonly present in pharmaceutical mixtures as trimebutine maleate salt form. … Trimebutine is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu opioid agonist effects.
Mixtures: RECBUTIN 120 MG/10 MG SUPOZITUVAR, 10 ADET, LIBERTRIM® SII 100 MGCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesMethylergometrine
go.drugbank.com/drugs/DB00353ApprovedInvestigationalA homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed)
International brands: Ingagen-M, Partan MCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsDoxycycline
go.drugbank.com/drugs/DB00254ApprovedInvestigationalVet approved[A174034] Doxycycline is used to treat a wide variety of gram-positive and gram-negative bacterial infections. It is also used to treat acne and malaria.[A251730]
Synonyms: 6α-deoxy-5-oxytetracycline, 5-hydroxy-α-6-deoxytetracyclineMixtures: BenzoDox 60 Kit, BenoxylDoxy 60 KitMethylprednisolone
go.drugbank.com/drugs/DB00959ApprovedInvestigationalVet approvedMethylprednisolone is a prednisolone derivative glucocorticoid with higher potency than prednisone. It was first described in the literature in the late 1950s. Methylprednisolone was granted FDA approval on 24 October 1957. In the outbre...
Mixtures: Physicians EZ Use M-pred, Physicians EZ Use M-predCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 InducersDasatinib
go.drugbank.com/drugs/DB01254ApprovedInvestigational[A2226,A11377] Also, mutations in the kinase domain of BCR-ABL may lead to relapse during imatinib treatment. … [A2226] The use of dasatinib was first approved by the FDA in 2006.[L45171,L45186]
Synonyms: N-(2-CHLORO-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamideCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 SubstratesBendamustine
go.drugbank.com/drugs/DB06769ApprovedInvestigationalBendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProducts: LEVACT 100 MG İNFÜZYONLUK ÇÖZELTİ İÇİN TOZ İÇEREN FLAKON , 5 ADET, LEVACT 25 MG İNFÜZYONLUK ÇÖZELTİ İÇİN TOZ İÇEREN FLAKON , 10 ADET