Methylergometrine is an ergot alkaloid used to prevent and control uterine atony and hemorrhage before and after delivery. A homolog of ergonovine containing one more CH2 group.
- Mechanism
- Curator reviewed
Methylergometrine acts directly on the smooth muscle of the uterus and increases the tone, rate, and amplitude of rhythmic contractions through binding and the resultant antagonism of the dopamine D1 receptor. Thus, it induces a rapid and sustained tetanic uterotonic effect which shortens the third stage of labor and reduces blood loss.
- Primary indication
- For the prevention and control of excessive bleeding following vaginal childbirthCurator reviewed · 6 structured indications
- Formula / weight
- C20H25N3O2 · 339.4314 g/mol (avg)
- First approval
- United States, 1946
- Also known as
- Ergotyl · Methylergobasin · Methylergonovine
- Code names
- ME 277
- Brand names
Resolves to
Clinical / RWD
Structure
InChIKey
UNBRKDKAWYKMIV-QWQRMKEZSA-NSMILES[H][C@@]12CC3=CNC4=CC=CC(=C34)C1=C[C@H](CN2C)C(=O)N[C@@H](CC)COTargets
What you can answer from here — as of September 23, 2026
2Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Methylergometrine, and which of those have an active Phase 3 trial?
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