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Displaying results 2791 - 2800 of 10000 in total
  1. Drug

    Dicirenone

    go.drugbank.com/drugs/DB20938
    Experimental

    Dicirenone is a small molecule drug. The usage of the INN stem '-renone' in the name indicates that Dicirenone is a mineralocorticoid receptor (MR, MCR, aldosterone receptor) antagonist. … Dicirenone has a monoisotopic molecular weight of 428.26 Da.

  2. Drug

    Capivasertib

    go.drugbank.com/drugs/DB12218
    ApprovedInvestigational

    This approval is based on favorable results obtained from the CAPItello-291 trial, where the combination of capivasertib and [fulvestrant] reduced the risk of disease progression or death by 50% versus … Therefore, targeting the PIK3/AKT pathway presents a promising approach for the treatment of breast cancer, leading to the development of capivasertib, a pan-AKT kinase inhibitor.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  3. Drug

    MT-0169

    go.drugbank.com/drugs/DB17430
    Investigational

    MT-0169 is a usion protein comprised of an enzymatically active Shiga-like toxin-I A1 subunit fused to a human single chain variable fragment with affinity for human CD38 cell surface protein.

  4. Drug

    Guanidine

    go.drugbank.com/drugs/DB00536
    Approved

    (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC. … A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism.

    Categories: MATE 1 Substrates, MATE 2 Substrates
  5. Drug

    UM-171

    go.drugbank.com/drugs/DB19449
    Investigational

    UM-171 is a pyrimidoindole derivative that is an agonist of ex vivo hematopoietic stem cell expansion and thus supports the expansion of hematopoietic stem cells.[A264868, A264873]

    Synonyms: ((1r, 4r)-n1-(2-benzyl-7-(2-methyl-2h-tetrazol-5-yl)-9h-pyrimido(4,5-b)indol-4-yl)cyclohexane-1,4-diamine, 1,4-cyclohexanediamine, n1-(7-(2-methyl-2h-tetrazol-5-yl)-2-(phenylmethyl)-9h-pyrimido(4,5-b)indol-4-yl)-, trans-
  6. Drug

    Relmapirazin

    go.drugbank.com/drugs/DB19130
    Investigational

    Relmapirazin is under investigation in clinical trial NCT05425719 (Pharmacokinetics and Safety of MB-102 (Relmapirazin) and the Medibeacon Transdermal GFR Measurement System in Evaluation of Kidney Function

    Categories: Heterocyclic Compounds, 1-RingSynonyms: D-serine, n,n'-((3,6-diamino-2,5-pyrazinediyl)dicarbonyl)bis-, N,n'-((3,6-diamino-2,5-pyrazinediyl)dicarbonyl)bis(d-serine)
  7. Drug

    Amiloxate

    go.drugbank.com/drugs/DB11207
    Approved

    Amiloxate is an EMA-approved chemical UV-filter found in over-the-counter sunscreen products at concentrations up to 10%m [F35]. … It is often referred to as isoamyl 4-methoxycinnamate or isoamyl p-methoxycinnamate. Amiloxate is a cinnamic acid derivative with an anti-inflammatory activity [A32916].

    Mixtures: Hansai Beestox Sun Cream SPF 50, a.c.care Bees Sun Protection UV Moisturizer SPF 50Synonyms: 3-(4-Methoxyphenyl)-2-propenoic acid, 3-methylbutyl ester, Isoamyl p-methoxycinnamate
  8. Drug

    Belnacasan

    go.drugbank.com/drugs/DB05507
    Investigational

    VX-765 is the orally available prodrug of a potent and selective competitive inhibitor of ICE/caspase-1 (VRT-043198). … VX-765 is currently under clinical development for the treatment of inflammatory and autoimmune conditions, as it blocks the hypersensitive response to an inflammatory stimulus.

  9. Drug

    Milsaperidone

    go.drugbank.com/drugs/DB24348
    ApprovedInvestigational

    [L56056] On February 20, 2026, milsaperidone was approved by the FDA for the treatment of Bipolar I Disorder and schizophrenia.[L56059] … [L56056] Atypical antipsychotic agents work by blocking the D2 dopamine and serotonin receptor signalling pathways.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: (S)-Hydroxy iloperidone
  10. Drug

    Omidenepag isopropyl

    go.drugbank.com/drugs/DB15071
    Approved

    [L43503] Omidenepag isopropyl is quickly metabolized to its active metabolite, omidenepag, a molecule with high selectivity and agonistic activity towards the prostaglandin E2 (EP2) receptor. … Omidenepag isopropyl is a topical ocular hypotensive agent used to reduce intraocular pressure (IOP) in patients with glaucoma and ocular hypertension.

    Categories: Receptors, Prostaglandin E, EP2 Subtype, agonists, Heterocyclic Compounds, 1-RingSynonyms: isopropyl N-(6-(((4-(1H-pyrazol-1-yl)benzyl)(3-pyridinylsulfonyl)amino)methyl)-2-pyridinyl)glycinate