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Displaying results 2811 - 2820 of 3180 in total
  1. Drug

    Dextrorphan

    go.drugbank.com/drugs/DB14682
    Experimental

    Synonyms: (+)-N-methylmorphinan-3-ol, d-3-hydroxy-N-methylmorphinanCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 Substrates
  2. Drug

    Interferon alfa-2b

    go.drugbank.com/drugs/DB00105
    ApprovedInvestigational

    Interferon alpha 2b (human leukocyte clone hif-sn 206 protein moiety reduced). A type I interferon consisting of 165 amino acid residues with arginine in position 23. This protein is produced by recombinant DNA technology and resembles i...

    Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 Enzyme Inhibitors
  3. Drug

    Ademetionine

    go.drugbank.com/drugs/DB00118
    ApprovedInvestigationalNutraceutical

    Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)

    Categories: Cytochrome P-450 CYP2E1 Inhibitors, Cytochrome P-450 Enzyme Inhibitors
  4. Drug

    Menadione

    go.drugbank.com/drugs/DB00170
    ApprovedNutraceutical

    A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.

    Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 CYP1A2 Inhibitors
  5. Drug

    Esmolol

    go.drugbank.com/drugs/DB00187
    ApprovedInvestigationalWithdrawn

    Esmolol, commonly marketed under the trade name Brevibloc, is a cardioselective beta-1 receptor blocker. It has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing acti...

    Synonyms: (±)-methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate, methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamateCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 Substrates
  6. Drug

    Pyrimethamine

    go.drugbank.com/drugs/DB00205
    ApprovedInvestigationalVet approved

    One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.

    Synonyms: 2,4-Diamino-5-(P-chlorophenyl)-6-ethylpyrimidineCategories: Cytochrome P-450 CYP2C8 Inhibitors, Cytochrome P-450 Enzyme Inhibitors
  7. Drug

    Reserpine

    go.drugbank.com/drugs/DB00206
    ApprovedWithdrawn

    An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon termin...

    Categories: P-glycoprotein inducers, P-glycoprotein inhibitors
  8. Drug

    Midodrine

    go.drugbank.com/drugs/DB00211
    ApprovedInvestigational

    An ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension.

    Synonyms: (±)-2-amino-N-(β-hydroxy-2,5-dimethoxyphenethyl)acetamide, DL-N1-(beta-Hydroxy-2,5-dimethoxyphenethyl)glycinamidCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 Substrates
  9. Drug

    Nelfinavir

    go.drugbank.com/drugs/DB00220
    ApprovedInvestigational

    Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the...

    Categories: P-glycoprotein inducers, P-glycoprotein inhibitors
  10. Drug

    Glimepiride

    go.drugbank.com/drugs/DB00222
    ApprovedInvestigational

    First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with ...

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 Substrates