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Orphenadrine
go.drugbank.com/drugs/DB01173ApprovedInvestigationalA muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
Mixtures: MYOGESIC-O, MYOGESIC-ORCategories: Ethers, Chemically Close to AntihistaminesAfamelanotide
go.drugbank.com/drugs/DB04931Approved[L9086] It differs structurally from its endogenous counterpart by only two amino acids - these structural differences improve biological efficacy by imparting a greater affinity for its target and a longer … [L9092] Despite its relatively recent approval, afamelanotide has been available for use as an orphan drug in both the US and EU since 2008.[L9122,L9125]
Categories: Protectives Against UV-Radiation for Systemic Use, Compounds used in a research, industrial, or household settingOxyphenonium
go.drugbank.com/drugs/DB00219ApprovedIt is used as an adjunct in the treatment of gastric and duodenal ulcer, and to relieve visceral spasms. The drug has also been used in the form of eye drops for mydriatic effect. [PubChem] … A quaternary ammonium anticholinergic agent with peripheral side effects similar to those of atropine.
Categories: Drugs for Functional Gastrointestinal DisordersQuinidine barbiturate
go.drugbank.com/drugs/DB01346ApprovedThe administration of quinidine derivatives helps to observe various skin and mucosal reactions.
Salsalate
go.drugbank.com/drugs/DB01399ApprovedInvestigationalSalsalate is a nonsteroidal anti-inflammatory agent for oral administration. … Such capacity limited biotransformation results in an increase in the half-life of salicylic acid from 3.5 to 16 or more hours.
Synonyms: o-Salicylsalicylic acid, O-SalicylcylsalicylsäureAbciximab
go.drugbank.com/drugs/DB00054ApprovedWithdrawnAbciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules … It also binds to vitronectin (αvβ3) receptor found on platelets and vessel wall endothelial and smooth muscle cells.
Fenfluramine
go.drugbank.com/drugs/DB00574ApprovedIllicitInvestigationalWithdrawn[A214688, A214691, A214700] Fenfluramine was granted initial FDA approval in 1973 prior to its withdrawal; it was granted a new FDA approval on June 25, 2020, for treatment of patients with Dravet syndrome … It is currently sold under the name FINTEPLA® by Zogenix INC.[L14522]
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeArmodafinil
go.drugbank.com/drugs/DB06413ApprovedInvestigationalArmodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep … apnea (OSA), narcolepsy, or shift work disorder (SWD).
Categories: Psychostimulants, Agents Used for ADHD and NootropicsNadofaragene firadenovec
go.drugbank.com/drugs/DB17381ApprovedInvestigationalIt is the first gene therapy approved by the FDA for the treatment of bladder cancer.[L44381,L44431] BCG-unresponsive NMIBC has a high recurrence and is notably difficult to treat. … The use of nadofaragene firadenovec provides a therapeutic alternative to patients seeking non-surgical alternatives for the treatment of BCG-unresponsive NMIBC.
Synonyms: TR-002Trifarotene
go.drugbank.com/drugs/DB12808ApprovedInvestigationalTrifarotene is a topical retinoid cream used in the treatment of acne vulgaris that was first approved for use in the United States in October 2019. … to vitamin A and are analogous only in function.
Categories: Anti-Acne Preparations for Topical Use, Retinoids for Topical Use in Acne