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Displaying results 2821 - 2830 of 10000 in total
  1. Drug

    Canagliflozin

    go.drugbank.com/drugs/DB08907
    ApprovedInvestigational

    It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 for a second indication of reducing the risk of cardiovascular events in patients diagnosed with type … Cardiovascular disease is the most common cause of death in these patients [A177083].

    Mixtures: VOKANAMET ® TM_TABLETAS RECUBIERTAS 150/1000 MGCategories: Drugs Used in Diabetes, Cytochrome P-450 Substrates
  2. Drug

    Diazepinomicin

    go.drugbank.com/drugs/DB12420
    Investigational

    Diazepinomicin has been used in trials studying the treatment of Glioblastoma Multiforme. … It is a proprietary first-in-class small molecule with the potential to treat multiple solid tumours like the well known chemotherapeutics, doxorubicin and mitomycin C.

    Synonyms: 4,6,8-trihydroxy-10-(3,7,11-trimethyldodeca-2,6,10-trienyl)-5,10-dihydrodibenzo(b,e)(1,4)diazepin-11-oneCategories: Heterocyclic Compounds, 3-Ring
  3. Drug

    Doxercalciferol

    go.drugbank.com/drugs/DB06410
    ApprovedInvestigational

    Doxercalciferol is a synthetic vitamin D2 analog that undergoes metabolic activation in vivo to form 1α,25-dihydroxyvitamin D2 (1α,25-(OH)2D2), a naturally occurring, biologically active form of vitamin … Doxercalciferol is indicated for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease on dialysis, as well as for the treatment of secondary hyperparathyroidism in patients

    Synonyms: 1-Hydroxyvitamin D2, 1α-hydroxyvitamin D2Categories: Vitamin D and Analogues
  4. Drug

    Influenza A virus A/Victoria/2454/2019 IVR-207 (H1N1) antigen (formaldehyde inactivated)

    go.drugbank.com/drugs/DB15705
    ApprovedInvestigationalWithdrawn

    Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed, or inactivated, through exposure to heat or chemicals such as formaldehyde 3. … In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated, or weakened, through various laboratory techniques.

    Synonyms: Influenza A virus A/Victoria/2454/2019 IVR-207 (H1N1) antigen (formaldehyde inactivated)Mixtures: FLUAD Injektionssuspension in einer Fertigspritze, Sandovac Injektionssuspension in einer Fertigspritze
  5. Drug

    AMG-222

    go.drugbank.com/drugs/DB06011
    Experimental

    Categories: DPP-IV Inhibitors, Heterocyclic Compounds, 1-Ring
  6. Drug

    Methyl aminolevulinate

    go.drugbank.com/drugs/DB00992
    ApprovedInvestigational

    Methyl aminolevulinate is a prodrug that is metabolised to Protoporphyrin IX (a photosensitizer) used in photodynamic therapy.

    Synonyms: Aminolevulinato de metilo, methyl 5-aminolevulinateCategories: Sensitizers Used in Photodynamic/radiation Therapy
  7. Drug

    Dostarlimab

    go.drugbank.com/drugs/DB15627
    ApprovedInvestigational

    A prospective phase II study in patients with mismatch repair-deficient locally advanced rectal cancer resulted in all twelve patients exhibiting a complete clinical response.[A248905] … [L33340] This indication was granted full FDA approval on February 10, 2023.[L45161] Dostarlimab-gxly was granted second accelerated approval for the treatment of solid tumours in the same month.

    Synonyms: Immunoglobulin G4, anti-programmed cell death protein 1 (PDCD1) (humanized clone ABT1 gamma4-chain), disulfide with humanized clone ABT1 kappa-chain, dimerCategories: PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitors, PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitors
  8. Drug

    Idebenone

    go.drugbank.com/drugs/DB09081
    ApprovedInvestigational

    More specifically, idebenone is thought to transfer electrons directly to complex III of the mitochondrial ETC, thereby circumventing complex I and restoring cellular energy (ATP) generation [L885]. … LHON is a mitochondrially inherited degeneration of retinal ganglion cells, resulting in acute central vision loss.

    Synonyms: 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-p-benzoquinone, 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-p-benzoquinoneMixtures: EVERON 90/5 MG FILM KAPLI TABLET ,50 TABLET, EVERON 90/5 MG FILM KAPLI TABLET ,100 TABLET
  9. Drug

    Chlordiazepoxide

    go.drugbank.com/drugs/DB00475
    ApprovedIllicit

    An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.

    Synonyms: 7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepin-4-oxideMixtures: Limbitrol DS
  10. Drug

    Influenza B virus B/Victoria/705/2018 BVR-11 antigen (formaldehyde inactivated)

    go.drugbank.com/drugs/DB15706
    ApprovedInvestigationalWithdrawn

    Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed, or inactivated, through exposure to heat or chemicals such as formaldehyde 3. … In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated, or weakened, through various laboratory techniques.

    Synonyms: Influenza B virus B/Victoria/705/2018 BVR-11 antigen (formaldehyde inactivated)Mixtures: FLUAD Injektionssuspension in einer Fertigspritze, Sandovac Injektionssuspension in einer Fertigspritze