Chlordiazepoxide is a benzodiazepine used to treat the withdrawal symptoms of acute alcoholism, to treat preoperative anxiety, and to treat anxiety over a short term period. An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties.
- Mechanism
- Curator reviewed
Chlordiazepoxide binds to stereospecific benzodiazepine (BZD) binding sites on GABA (A) receptor complexes at several sites within the central nervous system, including the limbic system and reticular formation. This results in an increased binding of the inhibitory neurotransmitter GABA to the GABA(A) receptor. BZDs, therefore, enhance GABA-mediated chloride influx through GABA receptor channels, causing membrane hyperpolarization. The net neuro-inhibitory effects result in the observed sedative, hypnotic, anxiolytic, and muscle relaxant properties.
- Primary indication
- Chlordiazepoxide is indicated for the management of anxiety disorders or for the short-term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety.Curator reviewed · 7 structured indications
- Formula / weight
- C16H14ClN3O · 299.755 g/mol (avg)
- First approval
- Canada, 1998 · United States, 1966
- Also known as
- Chloradiazepoxide · Clopoxide · Methaminodiazepoxide
- Brand names
Resolves to
ANTSCNMPPGJYLG-UHFFFAOYSA-NSMILESCNC1=NC2=C(C=C(Cl)C=C2)C(C2=CC=CC=C2)=[N+]([O-])C1What you can answer from here — as of September 13, 2026
Which drugs share a target with Chlordiazepoxide, and which of those have an active Phase 3 trial?
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