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Pimavanserin
go.drugbank.com/drugs/DB05316ApprovedInvestigational[L48241,A232573] Pimavanserin was also under review as a potential treatment for dementia-related psychosis; however, as of April 2021, FDA approval has not been granted for this indication despite previous
ZEN-012
go.drugbank.com/drugs/DB06042ExperimentalZEN-012 also expresses additional modes of action such as pro-apoptotic and anti-angiogenic properties. It is developed for the treatment of solid tumors.
Elacridar
go.drugbank.com/drugs/DB04881InvestigationalAs of August 2007 elacridar was not listed on GSK's product pipeline. Development is assumed to have been discontinued.
Lunacalcipol
go.drugbank.com/drugs/DB05024InvestigationalCytochroma anticipates that CTA018 will be more potent than currently marketed vitamin D analogues such as calcitriol and calcipotriol and it is expected to have a greater safety index. … Preclinical studies have shown that CTA018 inhibits the proliferation of rapidly dividing cells such as human epidermal keratinocytes (skin cells) and is also effective in inhibiting pro-inflammatory cytokine
Polyethylene glycol
go.drugbank.com/drugs/DB09287ApprovedInvestigationalVet approvedPolyethylene glycol (PEG) is a synthetic polymer produced via polymerization of ethylene oxide molecules to make joining units of ethylene glycol by an ether linkage. PEGs are water-soluble polymers that can form hydrogen bonds in a rati...
Lazertinib
go.drugbank.com/drugs/DB16216ApprovedInvestigationalLazertinib is an oral, third-generation, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). Lazertinib was first approved in South Korea on January 18, 2021, for the treatment of EGFR T790M mutation-positive non-sma...
Voriconazole
go.drugbank.com/drugs/DB00582ApprovedInvestigationalVoriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasiv...
Teduglutide
go.drugbank.com/drugs/DB08900ApprovedInvestigationalThe significance of this substitution is that teduglutide is longer acting than endogenous GLP-2 as it is more resistant to proteolysis from dipeptidyl peptidase-4. FDA approved on December 21, 2012.