Propoxycaine

DB09342ApprovedSmall molecule

Propoxycaine is a local anesthetic of the ester type that has a rapid onset of action and a longer duration of action than procaine hydrochloride . This drug was removed... Although no longer available in the United States, this medication was used in combination with procaine to aid in anesthesia during dental procedures.

Mechanism: Propoxycaine is a para-aminobenzoic acid ester with local anesthetic activity. Propoxycaine binds to and blocks voltage-gated sodium channels, thereby inhibiting the ionic flux essential for the conduction of nerve impulses. This results in a loss of sensation.
In one study, propoxycaine hydrochloride increased annular lipid fluidity in cell lipid bilayers and had a greater fluidizing effect on the inner monolayer than that of the outer monolayer. This may further confirm its role in modulating neural impulses.
Curator reviewed · 2 references
Primary indication: Propoxycaine is a local anesthetic medication.Curator reviewed
Formula / weight: C₁₆H₂₆N₂O₃ · 294.395 g/mol (avg)

Resolves to

Compound

UNIIEPD1EH7F53CAS86-43-1ChEMBLCHEMBL1195ChEBI8496PubChem6843KEGGC07895

Structure

InChIKeyCAJIGINSTLKQMM-UHFFFAOYSA-NSMILESCCCOC1=CC(N)=CC=C1C(=O)OCCN(CC)CC

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1,073Drug interactionsStructured to mechanism, not free text

13+ReferencesStructured and connected to the statements they support

Which companies are running trials of Propoxycaine, in which indications and phases, and which of those programs are still active?

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