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Trospium
go.drugbank.com/drugs/DB00209ApprovedInvestigationalTrospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably.
Categories: Cytochrome P-450 CYP2D6 Inhibitors, Cytochrome P-450 Enzyme InhibitorsProducts: SPASMEX 5, TROSBIO® 30 MGPantoprazole
go.drugbank.com/drugs/DB00213ApprovedInvestigationalPantoprazole exerts its stomach acid-suppressing effects by preventing the final step in gastric acid production by covalently binding to sulfhydryl groups of cysteines found on the (H+, K+)-ATPase enzyme … As the binding of pantoprazole to the (H+, K+)-ATPase enzyme is irreversible and new enzyme needs to be expressed in order to resume acid secretion, pantoprazole's duration of antisecretory effect persists
Mixtures: OCAM® DUO.Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsEletriptan
go.drugbank.com/drugs/DB00216ApprovedInvestigationalEletriptan is a second generation triptan drug developed by Pfizer Inc for the treatment of migraine headaches.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: RELPAX 40 MG FILM TABLET, 2 ADET, RELPAX 40 MG FILM TABLET, 4 ADETIndinavir
go.drugbank.com/drugs/DB00224ApprovedInvestigationalA potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem]
Categories: P-glycoprotein inducers, P-glycoprotein inhibitorsSynonyms: (1(1S,2R),5(S))-2,3,5-Trideoxy-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-(2-(((1,1-dimethylethyl)amino)carbonyl)-4-(3-pyridinylmethyl)-1-piperazinyl)-2-(phenylmethyl)-D-erythro-pentonamideGuanadrel
go.drugbank.com/drugs/DB00226ApprovedGuanadrel is an antihypertensive agent and postganglionic adrenergic blocking agent.
Aminosalicylic acid
go.drugbank.com/drugs/DB00233ApprovedInvestigationalAn antitubercular agent often administered in association with isoniazid. The sodium salt of the drug is better tolerated than the free acid.
Categories: 4-aminosalicylic acidSynonyms: 4-amino-2-hydroxybenzoic acid, 4-aminosalicylateButabarbital
go.drugbank.com/drugs/DB00237ApprovedIllicitWithdrawn[A19735] Its short duration of action gives butabarbital a high abuse potential, comparable to [secobarbital].[A201977,A201980] Butabarbital was granted FDA approval on 5 June 1939.[L13613] … Butabarbital, or Butisol, is a fast onset barbiturate with short duration of action compared to other barbiturates.
Categories: Heterocyclic Compounds, 1-RingSynonyms: 5-ethyl-5-(1-methylpropyl)barbituric acid, 5-ethyl-5-(1-methylpropyl)-2,4,6(1H,3H,5H)-pyrimidinetrioneBenzatropine
go.drugbank.com/drugs/DB00245ApprovedInvestigationalIt is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ether from the dialkylpiperazines determined to be a dopamine uptake inhibitor since 1970. … potency for dopamine uptake inhibition as well as a decreased inhibition of serotonin and norepinephrine.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesSynonyms: benzhydryl 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ether, 3α-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octanePhenytoin
go.drugbank.com/drugs/DB00252ApprovedInvestigationalVet approvedPhenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.
Mixtures: Dilantin W Phenobarbital 15mg, Dilantin W Phenobarbital 30mg CapCategories: Cytochrome P-450 CYP2A6 Substrates with a Narrow Therapeutic Index, P-glycoprotein substrates with a Narrow Therapeutic IndexDiethylstilbestrol
go.drugbank.com/drugs/DB00255ApprovedWithdrawnA synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. … According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSynonyms: (E)-3,4-bis(4-hydroxyphenyl)-3-hexene, α,α'-diethyl-(E)-4,4'-stilbenediol