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Thyroid, porcine
go.drugbank.com/drugs/DB09100ApprovedInvestigational[A190831] Thyroid extract is no longer considered a first line therapy as it delivers a dose that is inconsistent with the stated strength of the tablet. … [A190813] Thyroid extracts were never FDA approved as their use in the United States predates the FDA.[A190831]
Cocaine
go.drugbank.com/drugs/DB00907ApprovedIllicitInvestigationalIt is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. … An alkaloid ester extracted from the leaves of plants including coca.
Synonyms: L-Cocain, L-CocaineDesmopressin
go.drugbank.com/drugs/DB00035ApprovedInvestigationalFirst synthesized in the 1960s, desmopressin has remained a gold-standard therapy for water balance disorders due to its safety and long duration of action compared to natural AVP [A31661, A275461]. … On January 15, 2026, the FDA approved a new low-dose sublingual film formulation specifically for the treatment of nocturia in patients at high risk for fluid overload, utilizing a specialized delivery
Doxacurium
go.drugbank.com/drugs/DB01135ApprovedWithdrawnDoxacurium chloride is a long-acting, nondepolarizing skeletal muscle relaxant for intravenous administration.
Oxamniquine
go.drugbank.com/drugs/DB01096Approved(From Martidale, The Extra Pharmacopoeia, 31st ed, p121) … An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp.
Thallous chloride
go.drugbank.com/drugs/DB09316ApprovedWithdrawnThallous chloride (also known as Thallium(I) chloride) is a colourless solid intermediate in the isolation of thallium from its ores. … This solid crystallizes in the caesium chloride motif. It is used as a diagnostic radiopharmaceutical. It is used for diagnosis of heart and parathyroid problems.
Vilanterol
go.drugbank.com/drugs/DB09082ApprovedInvestigational[A259961] Vilanterol was designed based on the salmeterol molecular scaffold, particularly as a antedrug analog of salmeterol modification by modifying the salmeterol molecule to create homochiral compounds … [L46481,L44461,L44456] BREO ELLIPTA is the first vilanterol-containing product to be approved by the FDA in May 2013, followed by ANORO ELLIPTA in December 2013 and TRELEGY ELLIPTA in September 2020.
Anemarrhena asphodeloides root
go.drugbank.com/drugs/DB14590InvestigationalMixtures: YOUNGCELLOGY AIOS LV SerumHydroxocobalamin
go.drugbank.com/drugs/DB00200ApprovedInvestigationalIt is also used in cyanide poisoning, Leber's optic atrophy, and toxic amblyopia. … Hydroxocobalamin, also known as vitamin B12a and hydroxycobalamin, is an injectable form of vitamin B 12 that has been used therapeutically to treat vitamin B 12 deficiency.
Mixtures: TRIBEDOCE C/LCategories: Vitamin B ComplexLevomilnacipran
go.drugbank.com/drugs/DB08918ApprovedInvestigational[L47956] While levomilnacipran was previously investigated and proposed as a potential treatment for stroke in Europe, the EMA decided against this use.[L48011] … Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.
Synonyms: CYCLOPROPANECARBOXAMIDE, 2-(AMINOMETHYL)-N,N-DIETHYL-1-PHENYL-, (1S,2R)-