An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms... (From Martidale, The Extra Pharmacopoeia, 31st ed, p121).
- Mechanism
- Curator reviewed
Oxamniquine may associate with an irreversible inhibition of the nucleic acid metabolism of the parasites. A hypothesis has been put forth that the drug is activated by a single step, in which a schistosome sulfotransferase enzyme converts oxamniquine into an ester (probably acetate, phosphate, or sulfate). Subsequently, the ester spontaneously dissociates, the resulting electrophilic reactant is capable of alkylation of schistosome DNA.
- Primary indication
- For treatment of Schistosomiasis caused by Schistosoma mansoniCurator reviewed
- Formula / weight
- C14H21N3O3 · 279.3348 g/mol (avg)
- Code names
- UK-4261 · UK-4271
Resolves to
XCGYUJZMCCFSRP-UHFFFAOYSA-NSMILESCC(C)NCC1CCC2=CC(CO)=C(C=C2N1)[N+]([O-])=OWhat you can answer from here — as of September 23, 2026
Which companies are running trials of Oxamniquine, in which indications and phases, and which of those programs are still active?
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