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Serine/threonine-protein kinase Nek11
go.drugbank.com/bio_entities/BE0004758TargetHumansProtein kinase which plays an important role in the G2/M checkpoint response to DNA damage. … Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation
Synonyms: Never in mitosis A-related kinase 11Eladocagene exuparvovec
go.drugbank.com/drugs/DB16780ApprovedInvestigationaland rare genetic disorder that causes severe disability in pediatric patients. … [A253687] It was subsequently approved by the FDA in November 2024.[L51898,L51893]
Categories: Enzymes and Coenzymes, Alimentary Tract and MetabolismInfigratinib
go.drugbank.com/drugs/DB11886ApprovedInvestigationalWithdrawncholangiocarcinoma in adults with a fibroblast growth factor receptor 2 (FGFR2) fusion or another rearrangement as detected by an FDA-approved test. … [A198963] Infitratinib is a pan-FGFR inhibitor, as it is an ATP-competitive inhibitor of all four FGFR receptor subtypes.
Categories: Antineoplastic and Immunomodulating AgentsCasimersen
go.drugbank.com/drugs/DB14984ApprovedInvestigationalDuchenne muscular dystrophy (DMD) is an X-linked recessive allelic disorder characterized by a lack of functional dystrophin protein, which leads to progressive impairment of ambulatory, pulmonary, and … However, the specific mutations, and hence the precise exon skipping, targeted by each is different.
Categories: Nucleic Acids, Nucleotides, and Nucleosides, Compounds used in a research, industrial, or household settingMagaldrate
go.drugbank.com/drugs/DB08938ApprovedInvestigationalWithdrawnMagaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market.
Mixtures: M A L D I M, MAGALDRATE CON SIMETRICONACategories: Alimentary Tract and Metabolism, magaldrate and antiflatulentsDiphenylpyraline
go.drugbank.com/drugs/DB01146ApprovedDiphenylpyraline is an antihistamine. Antihistamines used in the treatment of allergy act by competing with histamine for H 1-receptor sites on effector cells. … Antihistamines antagonize, in varying degrees, most of the pharmacological effects of histamine, including urticaria and pruritus.
Synonyms: 4-(benzhydryloxy)-N-methylpiperidineEflapegrastim
go.drugbank.com/drugs/DB15001ApprovedInvestigational[L43135] In September 2022, eflapegrastim was approved by the US FDA as a prophylactic against infection, as manifested by febrile neutropenia, in patients receiving certain myelosuppressive anti-cancer … in which the patient develops an infection during a period of significant neutropenia.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsSerine/threonine-protein kinase Nek5
go.drugbank.com/bio_entities/BE0009499TargetHumansSynonyms: Never in mitosis A-related kinase 5Chloride anion exchanger
go.drugbank.com/bio_entities/BE0010211TransporterHumansPlays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity) … Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia (PubMed:16606687, PubMed:19321737, PubMed:22159084, PubMed:22627094).
Synonyms: Down-regulated in adenomaSerine/threonine-protein kinase Nek7
go.drugbank.com/bio_entities/BE0017593TargetHumansProtein kinase which plays an important role in mitotic cell cycle progression (PubMed:17101132, PubMed:19941817, PubMed:31409757). … Acts by unlocking NLRP3 following NLRP3 tranlocation into the microtubule organizing center (MTOC), relieving NLRP3 autoinhibition and promoting formation of the NLRP3:PYCARD complex, and activation of
Synonyms: Never in mitosis A-related kinase 7