Diphenylpyraline

DB01146ApprovedSmall moleculeHistamine H1 Antagonists

Diphenylpyraline is an antihistamine used for the treatment of allergic rhinitis, hay fever, and allergic skin disorders. Antihistamines used in the treatment of allergy act by competing with histamine for H 1-receptor sites on effector cells.

Chemical structure of Diphenylpyraline
Mechanism
Curator reviewed
Primary indication
For use in the treatment of allergic rhinitis, hay fever, and allergic skin disorders.Curator reviewed · 10 structured indications
Formula / weight
C19H23NO · 281.392 g/mol (avg)
First approval
Canada, 2007
Also known as
Diphenylpyralamine

Resolves to

Compound
UNII33361OE3AVCAS147-20-6ChEMBLCHEMBL1492ChEBI59788PubChem3103KEGGD07862
Clinical / RWD
RxNorm23386ATCR06AA07ATCR06AA57PharmGKBPA164746377
Structure
InChIKeyOWQUZNMMYNAXSL-UHFFFAOYSA-NSMILESCN1CCC(CC1)OC(C1=CC=CC=C1)C1=CC=CC=C1
Targets
P35367HRH1Q01959SLC6A3

What you can answer from here — as of September 13, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
36Drug interactionsStructured to mechanism, not free text
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3Clinical trialsPhase, status and sponsor resolved per trial
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10Structured indicationsCondition, population, route and combination as fields, not prose
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19Marketed productsAcross 3 countries and 15 labellers
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2ATC codesIncluding every combination product, plus 4 drug categories
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12+ReferencesStructured and connected to the statements they support
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