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Displaying results 2861 - 2870 of 10000 in total

Drug
Volixibat
go.drugbank.com/drugs/DB13914
Investigational
Volixibat, also known as SHP626 or LUM002, is an investigational drug that will potentially be used for the treatment of Non-Alcoholic Steatohepatitis (NASH). … Volixibat is a selective inhibitor of the apical sodium-dependent bile acid transporter (ASBT), a transmembrane protein primarily expressed by enterocytes of the ileum.
Categories: Heterocyclic Compounds, 2-Ring
Drug
Hydroxypropyl cellulose
go.drugbank.com/drugs/DB00840
Approved
As a food additive, hydroxypropyl cellulose is used as a thickener and as an emulsion stabilizer. … Hydroxypropyl cellulose is an ether of cellulose where some of the hydroxyl groups of the cellulose have been hydroxypropylated forming -OCH2CH(OH)CH3 groups.
Synonyms: Cellulose, 2-hydroxypropyl ether, Hydroxypropyl cellulose (type H)International brands: A-Gel
Drug
Chloroquine
go.drugbank.com/drugs/DB00608
ApprovedInvestigationalVet approved
Chloroquine is an aminoquinolone derivative first developed in the 1940s for the treatment of malaria. … [A191787] Chloroquine and its derivative [hydroxychloroquine] have since been repurposed for the treatment of a number of other conditions including HIV, systemic lupus erythematosus, and rheumatoid arthritis
Synonyms: N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamineInternational brands: Nivaquine B
Drug
3-hydroxyanthranilic acid
go.drugbank.com/drugs/DB03644
Experimental
An oxidation product of tryptophan metabolism. It may be a free radical scavenger and a carcinogen.
Synonyms: 2-Amino-3-hydroxy-benzoic acid, 2-Amino-3-Hydroxybenzoic AcidCategories: Compounds used in a research, industrial, or household setting
Drug
Teduglutide
go.drugbank.com/drugs/DB08900
ApprovedInvestigational
Teduglutide is a glucagon-like peptide-2 (GLP-2) analogue. It is made up of 33 amino acids and is manufactured using a strain of Escherichia coli modified by recombinant DNA technology. … Teduglutide differs from GLP-2 by one amino acid (alanine is substituted by glycine).
Synonyms: Gly(2)-GLP-2, (Gly2)GLP-2Categories: Glucagon-like Peptide-2 (GLP-2) Agonists, GLP-2 Analog
Drug
Thiethylperazine
go.drugbank.com/drugs/DB00372
ApprovedInvestigationalWithdrawn
A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins.
Synonyms: 2-(ethylthio)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazineCategories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 3-Ring
Target
Myocardin-related transcription factor A
go.drugbank.com/bio_entities/BE0004156
TargetHumans
Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SR...
Synonyms: MAL
Drug
Stepronin
go.drugbank.com/drugs/DB01423
Experimental
Strepronin is a mucolytic drug. A mucolytic agent is any agent which dissolves thick mucus usually used to help relieve respiratory difficulties.
Categories: Heterocyclic Compounds, 1-Ring
Drug
Bufexamac
go.drugbank.com/drugs/DB13346
ApprovedWithdrawn
The use of bufexamac has been discontinued in Canada and the United States, which may be due to undetermined clinical efficacy and a high prevalence of contact sensitization [A32822]. … Bufexamac is a non-steroidal anti-inflammatory drug (NSAID) under the market name Droxaryl, Malipuran, Paraderm and Parfenac.
Synonyms: 4-Butoxy-N-hydroxybenzeneacetamide, 2-(p-Butoxyphenyl)-acetohydroxamic acidCategories: Non COX-2 selective NSAIDS
Drug
Bazedoxifene
go.drugbank.com/drugs/DB06401
ApprovedInvestigational
Bazedoxifene is a third generation selective estrogen receptor modulator (SERM), developed by Pfizer following the completion of their takeover of Wyeth Pharmaceuticals.
Categories: Heterocyclic Compounds, 2-Ring