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Displaying results 2861 - 2870 of 10000 in total
  1. Drug

    Ziprasidone

    go.drugbank.com/drugs/DB00246
    ApprovedInvestigational

    [A180748] Although ziprasidone is classified as an atypical antipsychotic, it appears to have a lower incidence of metabolic adverse effects compared to other medications in the same class.[A190525] … [A180748] It can effectively reduce the rate and time of relapses in schizophrenia, and can be used to treat manic episodes in bipolar disorder although the mechanism of action is unknown.

    Categories: Adrenergic alpha-1 Receptor Antagonists, Heterocyclic Compounds, 1-RingProducts: Zeldox 10 mg/ml Suspension zum Einnehmen, ZELDOX 20 MG KAPSUL, 56 ADET
  2. Drug

    Avelumab

    go.drugbank.com/drugs/DB11945
    ApprovedInvestigational

    Avelumab is a human IgG1 lambda monoclonal antibody that binds programmed cell death ligand-1 (PD-L1) to block its interaction with its receptors found on T cells and antigen-presenting cells. … [A261496] On September 18 and December 18 of the same year, it was also granted approval by EMA [L48126] and Health Canada,[L48171] respectively.

    Categories: PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitors, PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitorsProducts: BAVENCIO 200 MG/10 ML IV İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 FLAKON, BAVENCIO 200 mg/10mL concentrate for solution for infusion
  3. Drug

    Tretinoin

    go.drugbank.com/drugs/DB00755
    ApprovedInvestigationalNutraceutical

    [A257689] In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. … [A257474] It is an oxidation product in the physiological pathway of vitamin A metabolism.

    Synonyms: Tretin M, (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acidInternational brands: Stieva-A
  4. Drug

    Minnelide

    go.drugbank.com/drugs/DB17309
    Investigational

    Synonyms: Trisoxireno(4b,5:6,7:8a,9)phenanthro(1,2-c)furan-1(3h)-one, 3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-8b-methyl-6a-(1-methylethyl)-6-((phosphonooxy)methoxy)-, sodium salt (1:2), (3bs,4as,5ar,6r,6as,7as,7bs,, 14-o-phosphonooxymethyltriptolide disodium salt
  5. Drug

    Prazosin

    go.drugbank.com/drugs/DB00457
    ApprovedInvestigational

    [L5828] It belongs to the class of drugs known as alpha-1 antagonists. … Prazosin is a drug used to treat hypertension. Prazosin is marketed by _Pfizer_ and was initially approved by the FDA in 1988.

    Synonyms: 2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline, 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazineCategories: Peripheral alpha-1 blockers, Adrenergic alpha-1 Receptor Antagonists
  6. Drug

    Rasagiline

    go.drugbank.com/drugs/DB01367
    ApprovedInvestigational

    Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases.

    Synonyms: (1R)-N-propargylindan-1-amine, (R)-N-2-Propynyl-1-indanamineCategories: Cytochrome P-450 Substrates, Monoamine Oxidase B Inhibitors
  7. Drug

    Tropicamide

    go.drugbank.com/drugs/DB00809
    Approved

    [A229958] It is also used in combination with [hydroxyamphetamine] for the same indication. … Tropicamide is an alkaloid atropine‐derived anticholinergic drug and a non‐selective antagonist of muscarinic acetylcholine (mACh) receptors.

    Mixtures: MYDRIASERT 0,28 MG/5,4 MG GÖZ INSERTI ,10 INSERT, Mydrane 0,2 mg/ml + 3,1 mg/ml + 10 mg/ml InjektionslösungCategories: Heterocyclic Compounds, 1-Ring
  8. Drug

    Carvedilol

    go.drugbank.com/drugs/DB01136
    ApprovedInvestigational

    Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker. … [L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.

    Mixtures: Co-Dilatrend 25 mg/12,5 mg - Filmtabletten, CARIVALAN 25/5Categories: Adrenergic alpha-1 Receptor Antagonists, Adrenergic beta-1 Receptor Antagonists
  9. Drug

    Ramucirumab

    go.drugbank.com/drugs/DB05578
    ApprovedInvestigational

    In contrast to other agents directed against VEGFR-2, ramucirumab binds a specific epitope on the extracellular domain of VEGFR-2, thereby blocking all VEGF ligands from binding to it. … VEGFR stimulation also mediates downstream signalling required for angiogenesis and is postulated to be heavily involved in cancer progression, making it a highly likely drug target.

    Categories: Vascular Endothelial Growth Factor Receptor 2 AntagonistProducts: CYRAMZA 500 MG/50 ML İNFÜZYONLUK ÇÖZELTİ KONSANTRESİ İÇEREN FLAKON, 1 ADET, CYRAMZA 100MG/10 ML INFÜZYONLUK ÇÖZELTI KONSANTRESI IÇEREN FLAKON, 1 ADET
  10. Drug

    Eptifibatide

    go.drugbank.com/drugs/DB00063
    ApprovedInvestigational

    Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics.

    Products: EPTICARD 20 MG/10 ML IV ENJEKSİYONLUK ÇÖZELTİ İÇEREN FLAKON, 1 ADET, INTEGRILIN INYECTABLE 2 MG/ML.