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Levomefolic acid
go.drugbank.com/drugs/DB11256ApprovedIt is available commercially as a crystalline form of the calcium salt (Metafolin(R)), which has the stability required for use as a supplement [A19276]. … Levomefolate is approved as a food additive and is designated a GRAS (generally regarded as safe) compound [L773].
Mixtures: PNV Tabs 20-1, Obstetrix ECCategories: Vitamin B Complex, Heterocyclic Compounds, 2-RingIC41
go.drugbank.com/drugs/DB05776InvestigationalIC41 is a therapeutic peptide vaccine. It is being devloped by Intercell AG for the treatment of hepatitis C. … The vaccine consists of five synthetic peptides (IPEP83, 84, 87, 89,1426) harboring HCV CD4 and CD8 T-cell epitopes and the synthetic adjuvant poly-L-arginine.
Phosphoaminophosphonic acid guanylate ester
go.drugbank.com/drugs/DB02082ExperimentalA non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the presence of Mg2+. … The nucleotide is a potent stimulator of adenylate cyclase.
Categories: Heterocyclic Compounds, 2-RingSynonyms: Gpp(NH)p, 5'-guanylylimidodiphosphatealpha-Linolenic acid
go.drugbank.com/drugs/DB00132ApprovedInvestigationalNutraceuticalWithdrawnAlpha-linolenic acid (ALA) is a polyunsaturated omega-3 fatty acid. It is a component of many common vegetable oils and is important to human nutrition.
Synonyms: (Z,Z,Z)-9,12,15-octadecatrienoic acid, α-linolenic acidMixtures: SIMILAC ALIMENTUM 400 G TOZ, PRIM E CAPSULEThymol
go.drugbank.com/drugs/DB02513ApprovedInvestigationalIt has been used for its antiseptic, antibacterial, and antifungal actions, and was formerly used as a vermifuge. (Dorland, 28th ed) … A phenol obtained from thyme oil or other volatile oils. It is used as a stabilizer in pharmaceutic preparations.
Synonyms: 5-Methyl-2-(1-Methylethyl)Phenol, 2-isopropyl-5-methylphenolMixtures: VICKS VAPORUB BUHARLASAN MERHEM, 1 ADETOleic Acid
go.drugbank.com/drugs/DB04224ApprovedInvestigationalVet approvedIt is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed)
Mixtures: Huile D'onagre Vitamin ETelisotuzumab vedotin
go.drugbank.com/drugs/DB15104ApprovedInvestigational[L53158] The c-Met protein is found to be overexpressed in approximately 25% of advanced EGFR wild type, non-squamous NSCLC patients and is associated with poor prognosis and limited treatment options. … Telisotuzumab vedotin is an antibody-drug conjugate comprising [telisotuzumab], a c-Met-directed humanized IgG1κ monoclonal antibody, conjugated to monomethyl auristatin E (MMAE), a small molecule microtubule-disrupting
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsSamidorphan
go.drugbank.com/drugs/DB12543ApprovedInvestigationalby Alkermes Inc. … [A235638, A235643] Samidorphan is a novel opioid antagonist structurally related to [naltrexone], with a higher affinity for opioid receptors, more potent μ-opioid receptor antagonism, higher oral bioavailability
Salts: Samidorphan L-malateCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesTirbanibulin
go.drugbank.com/drugs/DB06137ApprovedInvestigationalTirbanibulin (KX-O1 or KX2–391) is a dual inhibitor of Src Kinase and tubulin. … [L27806] Actinic keratosis is a chronic condition characterized by lesions, which can potentially transform into invasive squamous cell carcinoma with a risk of 1% over 10 years.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsNefazodone
go.drugbank.com/drugs/DB01149ApprovedWithdrawnOn May 20, 2004, Bristol-Myers Squibb discontinued the sale of Serzone in the United States. … Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or even death, with the incidence of severe liver damage was shown to be approximately 1 in 250,000 to
Synonyms: 1-(3-(4-(m-Chlorophenyl)-1-piperazinyl)propyl)-3-ethyl-4-(2-phenoxyethyl)-delta2-1,2,4-triazolin-5-oneCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inhibitors