Identification

Summary

Thymol is an essential oil found in various over-the-counter antibacterial and antifungal products.

Brand Names
Listerine Antiseptic
Generic Name
Thymol
DrugBank Accession Number
DB02513
Background

A phenol obtained from thyme oil or other volatile oils. It is used as a stabilizer in pharmaceutic preparations. It has been used for its antiseptic, antibacterial, and antifungal actions, and was formerly used as a vermifuge. (Dorland, 28th ed)

Type
Small Molecule
Groups
Approved
Structure
Thumb
Weight
Average: 150.2176
Monoisotopic: 150.10446507
Chemical Formula
C10H14O
Synonyms
  • 2-isopropyl-5-methylphenol
  • 5-Methyl-2-(1-Methylethyl)Phenol
  • IPMP
External IDs
  • FEMA NO. 3066
  • NSC-11215
  • NSC-47821
  • NSC-49142

Pharmacology

Indication

Not Available

Pharmacology
Reduce drug development failure rates
Build, train, & validate machine-learning models
with evidence-based and structured datasets.
See how
Build, train, & validate predictive machine-learning models with structured datasets.
See how
Associated Conditions
Associated Therapies
Contraindications & Blackbox Warnings
Contraindications
Avoid life-threatening adverse drug events
Improve clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.
Learn more
Avoid life-threatening adverse drug events & improve clinical decision support.
Learn more
Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Hover over products below to view reaction partners

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
Improve decision support & research outcomes
With structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.
Learn more
Improve decision support & research outcomes with our structured adverse effects data.
Learn more
Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcenocoumarolThe therapeutic efficacy of Acenocoumarol can be increased when used in combination with Thymol.
DicoumarolThe therapeutic efficacy of Dicoumarol can be increased when used in combination with Thymol.
FluindioneThe therapeutic efficacy of Fluindione can be increased when used in combination with Thymol.
PhenindioneThe therapeutic efficacy of Phenindione can be increased when used in combination with Thymol.
PhenprocoumonThe therapeutic efficacy of Phenprocoumon can be increased when used in combination with Thymol.
WarfarinThe therapeutic efficacy of Warfarin can be increased when used in combination with Thymol.
Interactions
Identify potential medication risks
Easily compare up to 40 drugs with our drug interaction checker.
Get severity rating, description, and management advice.
Learn more
Food Interactions
No interactions found.

Products

Products2
Drug product information from 10+ global regions
Our datasets provide approved product information including:
dosage, form, labeller, route of administration, and marketing period.
Access now
Access drug product information from over 10 global regions.
Access now
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Acne Vanish Synergy for treatment of AcnesOil0.7 g/50gTopicalPhytopia Co., Ltd.2016-02-29Not applicableUS flag
Acute Bronchitis SynergyOil1.5 g/50gTopicalPhytopia Co., Ltd.2016-02-29Not applicableUS flag
All Clear Antibacterial SolutionLiquid0.03 g/100mLTopicalFroggy's Fog LLC2020-03-30Not applicableUS flag
Benefect Natural Hand SanitizerSpray.06 mL/120mLTopicalSensible Life Products2010-03-01Not applicableUS flag
Benefect Natural Hand SanitizerLiquid.5 mL/1LTopicalSensible Life Products2010-03-01Not applicableUS flag
Chronic Bronchitis SynergyOil0.5 g/50gTopicalPhytopia Co., Ltd.2016-02-29Not applicableUS flag
Cleanwell Natural Antibacterial Foaming LavenderSoap0.0004 kg/1kgTopicalCleanWell, LLC2007-11-012019-05-29US flag
CleanWell Natural Antibacterial Foaming Orange VanillaSoap0.0004 1/1kgTopicalCleanWell, LLC2007-11-012019-05-29US flag
CleanWell Natural Antibacterial Foaming Spearmint LimeSoap0.0004 kg/1kgTopicalCleanWell, LLC2007-11-012019-05-29US flag
CleanWell Natural Orange Vanilla Hand SanitizerSpray0.0005 kg/1kgTopicalCleanWell, LLC2007-11-01Not applicableUS flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Advanced AntisepticThymol (.064 mL/100L) + Eucalyptol (.042 mL/100L) + Levomenthol (.042 mL/100L) + Methyl salicylate (.060 mL/100L)MouthwashOralWakfern Food Corporation2010-11-24Not applicableUS flag
Advanced AntisepticThymol (.064 kg/100L) + Eucalyptol (.092 kg/100L) + Levomenthol (.042 kg/100L) + Methyl salicylate (.060 kg/100L)MouthwashOralDemoulas Supermarkets, Inc.2010-07-22Not applicableUS flag
Advanced Antiseptic CitrusThymol (.042 mL/100L) + Eucalyptol (.092 mL/100L) + Levomenthol (.042 mL/100L) + Methyl salicylate (.060 mL/100L)MouthwashOralH.E.B.2010-10-15Not applicableUS flag
Advanced Antiseptic CitrusThymol (.042 mL/100L) + Eucalyptol (.092 mL/100L) + Levomenthol (.042 mL/100L) + Methyl salicylate (.060 mL/100L)MouthwashOralDrug Mart1991-06-15Not applicableUS flag
Advanced CitrusThymol (.064 kg/100L) + Eucalyptol (.092 kg/100L) + Levomenthol (.042 kg/100L) + Methyl salicylate (.060 kg/100L)MouthwashOralWalmart Stores2010-07-22Not applicableUS flag
Advanced Citrus AntisepticThymol (.064 mL/100L) + Eucalyptol (.092 mL/100L) + Levomenthol (.042 mL/100L) + Methyl salicylate (.060 mL/100L)MouthwashOralPublix Supermarkets, Inc.2001-05-03Not applicableUS flag
Amber Mouth RinseThymol (0.64 mg/1mL) + Eucalyptol (0.92 mg/1mL) + Levomenthol (0.42 mg/1mL) + Methyl salicylate (0.6 mg/1mL)LiquidOralFilo America2013-07-30Not applicableUS flag
Amber Mouth Wash - LiqThymol (0.064 %) + Eucalyptol (0.092 %) + Levomenthol (0.042 %)LiquidDentalPerrigo International1996-10-091999-08-06Canada flag
Amber Mouthwash - LiqThymol (0.064 %) + Eucalyptol (0.092 %) + Levomenthol (0.042 %)LiquidDentalPerrigo International1996-06-301999-08-06Canada flag
Anitseptic Mouth RinseThymol (0.64 mg/1mL) + Eucalyptol (0.92 mg/1mL) + Levomenthol (0.42 mg/1mL) + Methyl salicylate (0.60 mg/1mL)MouthwashOralPharmacy Value Alliance LLC2003-08-19Not applicableUS flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Antiseptic RinseThymol (.064 kg/100L) + Eucalyptol (.092 kg/100L) + Levomenthol (.042 kg/100L) + Methyl salicylate (.060 kg/100L)MouthwashOralMeijer2006-08-08Not applicableUS flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as aromatic monoterpenoids. These are monoterpenoids containing at least one aromatic ring.
Kingdom
Organic compounds
Super Class
Lipids and lipid-like molecules
Class
Prenol lipids
Sub Class
Monoterpenoids
Direct Parent
Aromatic monoterpenoids
Alternative Parents
Monocyclic monoterpenoids / Phenylpropanes / Cumenes / Meta cresols / Toluenes / 1-hydroxy-4-unsubstituted benzenoids / 1-hydroxy-2-unsubstituted benzenoids / Organooxygen compounds / Hydrocarbon derivatives
Substituents
1-hydroxy-2-unsubstituted benzenoid / 1-hydroxy-4-unsubstituted benzenoid / Aromatic homomonocyclic compound / Aromatic monoterpenoid / Benzenoid / Cumene / Hydrocarbon derivative / M-cresol / Monocyclic benzene moiety / Monocyclic monoterpenoid
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
phenols, monoterpenoid (CHEBI:27607) / Menthane monoterpenoids, Cyclic monoterpenes (C09908) / Menthane monoterpenoids (LMPR0102090029)
Affected organisms
Not Available

Chemical Identifiers

UNII
3J50XA376E
CAS number
89-83-8
InChI Key
MGSRCZKZVOBKFT-UHFFFAOYSA-N
InChI
InChI=1S/C10H14O/c1-7(2)9-5-4-8(3)6-10(9)11/h4-7,11H,1-3H3
IUPAC Name
5-methyl-2-(propan-2-yl)phenol
SMILES
CC(C)C1=CC=C(C)C=C1O

References

General References
Not Available
Human Metabolome Database
HMDB0001878
KEGG Drug
D01039
KEGG Compound
C09908
PubChem Compound
6989
PubChem Substance
46504674
ChemSpider
21105998
BindingDB
50240432
RxNav
10553
ChEBI
27607
ChEMBL
CHEMBL29411
ZINC
ZINC000000967597
Guide to Pharmacology
GtP Drug Page
PDBe Ligand
IPB
Wikipedia
Thymol
PDB Entries
1e06

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4WithdrawnPreventionCaries / Periodontal Disease (Diagnosis)1
2Not Yet RecruitingPreventionGonorrhea1
Not AvailableUnknown StatusTreatmentPeriodontitis / Type 2 Diabetes Mellitus1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
OilTopical0.7 g/50g
LiquidTopical0.03 g/100mL
LiquidDental
RinseOral
MouthwashOral
MouthwashBuccal
LiquidTopical
LiquidTopical.5 mL/1L
SprayTopical.06 mL/120mL
LotionTopical
SprayTopical
PowderTopical
OilTopical0.5 g/50g
SoapTopical0.0004 1/1kg
SoapTopical0.0004 kg/1kg
SprayTopical0.0005 kg/1kg
ClothTopical0.0005 kg/1kg
OilTopical1.5 g/50g
MouthwashBuccal; Oral
GelTransdermal
PatchTransdermal
LiquidTopical0.3 g/100mL
GelTopical
Solution, concentrateOral
PatchTopical
OilTopical1.7 g/50g
MouthwashDental; Oral
SprayOral
SolutionTopical60 mg/100ml
JellyNasal
SoapTopical0.0024 kg/1kg
PlasterTopical
MouthwashOral
LozengeOral
LiquidOral
PlasterTransdermal
StickTopical
PatchCutaneous; Topical; Transdermal
MouthwashDental
SprayOral0.05 g/100mL
OintmentTopical
LiquidRespiratory (inhalation)
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)51.5 °CPhysProp
boiling point (°C)232.5 °CPhysProp
water solubility900 mg/L (at 20 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP3.30HANSCH,C ET AL. (1995)
pKa10.6 (at 20 °C)SERJEANT,EP & DEMPSEY,B (1979)
Predicted Properties
PropertyValueSource
Water Solubility0.643 mg/mLALOGPS
logP3.16ALOGPS
logP3.43ChemAxon
logS-2.4ALOGPS
pKa (Strongest Acidic)10.59ChemAxon
pKa (Strongest Basic)-5.2ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area20.23 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity47.27 m3·mol-1ChemAxon
Polarizability17.84 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
PropertyValueProbability
Human Intestinal Absorption+0.9955
Blood Brain Barrier+0.9381
Caco-2 permeable+0.9153
P-glycoprotein substrateNon-substrate0.722
P-glycoprotein inhibitor INon-inhibitor0.9343
P-glycoprotein inhibitor IINon-inhibitor0.9883
Renal organic cation transporterNon-inhibitor0.9036
CYP450 2C9 substrateNon-substrate0.7352
CYP450 2D6 substrateSubstrate0.7838
CYP450 3A4 substrateNon-substrate0.5667
CYP450 1A2 substrateInhibitor0.9107
CYP450 2C9 inhibitorNon-inhibitor0.907
CYP450 2D6 inhibitorNon-inhibitor0.9368
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorNon-inhibitor0.9196
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7429
Ames testNon AMES toxic0.9282
CarcinogenicityNon-carcinogens0.7195
BiodegradationNot ready biodegradable0.7808
Rat acute toxicity2.2996 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8987
hERG inhibition (predictor II)Non-inhibitor0.9087
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
GC-MS Spectrum - EI-BGC-MSsplash10-000i-0900000000-333dc57384e65e3b4cfa
GC-MS Spectrum - EI-BGC-MSsplash10-000i-1900000000-3679938a5ea114a30e48
GC-MS Spectrum - EI-BGC-MSsplash10-000i-3900000000-8ce5865e48dad7250d5e
GC-MS Spectrum - EI-BGC-MSsplash10-0udi-0109030000-5562c203cb318f30321b
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-0a4i-2492200000-85342d698be72263a95f
Mass Spectrum (Electron Ionization)MSsplash10-000i-4900000000-73edaa628c1f5f2e1bd9
MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)LC-MS/MSsplash10-01p9-9700000000-e1a28495617d7b014e5c
MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)LC-MS/MSsplash10-014i-9300000000-baeee6cdcafaadeebdec
MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)LC-MS/MSsplash10-015c-9100000000-e1efa41eaf818832448a
MS/MS Spectrum - EI-B (SHIMADZU LKB-9000B) , PositiveLC-MS/MSsplash10-000i-0900000000-333dc57384e65e3b4cfa
MS/MS Spectrum - EI-B (HITACHI RMU-6L) , PositiveLC-MS/MSsplash10-000i-1900000000-3679938a5ea114a30e48
MS/MS Spectrum - EI-B (HITACHI M-80B) , PositiveLC-MS/MSsplash10-000i-3900000000-f72f603d97f0f7081b8d
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
1H NMR Spectrum1D NMRNot Applicable
13C NMR Spectrum1D NMRNot Applicable
[1H,13C] 2D NMR Spectrum2D NMRNot Applicable

Drug created at June 13, 2005 13:24 / Updated at June 12, 2020 16:52