Phosphoaminophosphonic acid guanylate ester

DB02082ExperimentalSmall molecule

A non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the... The nucleotide is a potent stimulator of adenylate cyclase.

Formula / weight: C₁₀H₁₇N₆O₁₃P₃ · 522.1957 g/mol (avg)
Also known as: 5'-guanylylimidodiphosphate · GMP-PNP · Gpp(NH)p · Guanosine 5'-[beta,gamma-imido]triphosphate · Guanylyl imidodiphosphate

Resolves to

Compound

UNII9L7GM5N7EGCAS34273-04-6ChEMBLCHEMBL1233085ChEBI78408PubChem36735

Structure

InChIKeyUQABYHGXWYXDTK-UUOKFMHZSA-NSMILESNC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1

Targets

Q92930RAB8B

What you can answer from here — as of September 12, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1+ReferenceStructured and connected to the statements they support

Which drugs share a target with Phosphoaminophosphonic acid guanylate ester, and which of those have an active Phase 3 trial?

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