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Pralsetinib
go.drugbank.com/drugs/DB15822ApprovedInvestigationalPralsetinib, similar to the previously approved [selpercatinib], is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes. … It is currently marketed under the brand name GAVRETO™ by Blueprint Medicines.[L15986]
Categories: MATE 1 Inhibitors, MATE 2 InhibitorsFactor XIII (human)
go.drugbank.com/drugs/DB12909ApprovedInvestigationalAs the half-life of endogenous Factor XIII is long (5-11 days), prophylactic therapy with the replacement of FXIII can be given every 4-6 to maintain hemostasis[A32363]. … When activated by thrombin at the site of injury, the FXIII pro-enzyme is cleaved resulting in activation of the catalytic A-subunit and dissociation from its carrier B-subunit.
International brands: Fibrogammin PProducts: Fibrogammin 1250 IE Pulver und Lösungsmittel zur Herstellung einer Injektions-/Infusionslösung, Fibrogammin 250 IE Pulver und Lösungsmittel zur Herstellung einer Injektions-/InfusionslösungImiquimod
go.drugbank.com/drugs/DB00724ApprovedInvestigationalImiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist. Imiquimod is commonly used topically to treat warts on the skin of the genital and anal areas. … Miquimod is also used to treat a skin condition of the face and scalp called actinic keratoses and certain types of skin cancer called superficial basal cell carcinoma.
Synonyms: 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine, 4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinolineMixtures: Imiquimod 5% / Levocetirizine Dihydrochloride 1% / Niacinamide 2%, Imiquimod 5% / Niacinamide 4%Insulin lispro
go.drugbank.com/drugs/DB00046ApprovedInvestigationalInsulin is released from the pancreas following a meal to promote the uptake of glucose from the blood into internal organs and tissues such as the liver, fat cells, and skeletal muscle. … Due to its duration of action of around 5 hours, Humalog is considered "bolus insulin" as it provides high levels of insulin in a short period of time to mimic the release of endogenous insulin from the
Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 Enzyme InducersProducts: HUMALOG KWIKPEN®200 U / ML, ADMELOG®Methdilazine
go.drugbank.com/drugs/DB00902ApprovedMethdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus.
Categories: Heterocyclic Compounds, 3-RingAgkistrodon piscivorus antivenin
go.drugbank.com/drugs/DB13894ApprovedThe cottonmouth, Agkistrodon piscivorus, is a large, venomous snake in the pit viper subfamily (Crotalinae). … As the only semi-aquatic viper species, cottonmouth snakes are strong swimmers and are frequently found in or near water [L2888]. This species of snake is endemic to the United States.
Terfenadine
go.drugbank.com/drugs/DB00342ApprovedWithdrawnIn the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation.
Synonyms: (RS)-1-(4-tert-butylphenyl)-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}-butan-1-olCategories: P-glycoprotein inhibitors, P-glycoprotein substratesCoccidioides immitis spherule
go.drugbank.com/drugs/DB11294ApprovedCoccidioides immitis spherule is a skin test antigen indicated to detect delayed-type hypersensitivity to Coccidioides immitis in individuals with a history of pulmonary coccidioidomycosis.
Vibegron
go.drugbank.com/drugs/DB14895ApprovedInvestigationalVibegron is a potent, selective beta-3 adrenergic receptor (β3) agonist that relaxes the detrusor smooth muscle of the bladder, thereby increasing bladder capacity. … On December 23, 2020, vibegron was approved for the same indication in adults. It is available as oral tablets under the market name GEMTESA.
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesQuizartinib
go.drugbank.com/drugs/DB12874ApprovedInvestigational[A260651] Therefore, quizartinib is proven to be a beneficial addition to the current AML treatment regimen, although serious side effects such as QT prolongation necessitates further research to optimize … cytarabine consolidation, followed by a maintenance monotherapy resulted in a 22% reduction in the risk of death.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesSynonyms: N-(5-(1,1-Dimethylethyl)isoxazol-3-yl)-N'-(4-(7-(2-(morpholin-4-yl)ethoxy)imidazo(2,1-b)benzothiazol-2-yl)phenyl)urea