Terfenadine is an antihistamine for the treatment of allergy symptoms. In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation.
- Mechanism
- Curator reviewed
Terfenadine competes with histamine for binding at H1-receptor sites in the GI tract, uterus, large blood vessels, and bronchial muscle. This reversible binding of terfenadine to H1-receptors suppresses the formation of edema, flare, and pruritus resulting from histaminic activity. As the drug does not readily cross the blood-brain barrier, CNS depression is minimal.
- Primary indication
- For the treatment of allergic rhinitis, hay fever, and allergic skin disorders.Curator reviewed · 4 structured indications
- Formula / weight
- C32H41NO2 · 471.6734 g/mol (avg)
- First approval
- Canada, 1983
- Also known as
- Terfenadin
- Code names
- RMI 9918
Resolves to
GUGOEEXESWIERI-UHFFFAOYSA-NSMILESCC(C)(C)C1=CC=C(C=C1)C(O)CCCN1CCC(CC1)C(O)(C1=CC=CC=C1)C1=CC=CC=C1What you can answer from here — as of September 23, 2026
Which drugs share a target with Terfenadine, and which of those have an active Phase 3 trial?
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