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Erlotinib
go.drugbank.com/drugs/DB00530ApprovedInvestigationalRecent studies demonstrate that erlotinib is also a potent inhibitor of JAK2V617F, which is a mutant form of tyrosine kinase JAK2 found in most patients with polycythemia vera (PV) and a substantial proportion … This finding introduces the potential use of erlotinib in the treatment of JAK2V617F-positive PV and other myeloproliferative disorders.
Categories: Antineoplastic and Immunomodulating Agents, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexSynonyms: [6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amineCoagulation factor VIIa Recombinant Human
go.drugbank.com/drugs/DB00036ApprovedInvestigationalNovoSeven is a vitamin K-dependent glycoprotein consisting of 406 amino acid residues. Cloned and expressed in hamster kidney cells, the protein is catalytically active in a two-chain form.
Categories: Increased Coagulation Factor X Activity, Enzymes and CoenzymesProducts: NOVOSEVENRT 5 MG, NOVOSEVEN RT 1 MGUmeclidinium
go.drugbank.com/drugs/DB09076ApprovedInvestigationalCOPD is a progressive obstructive lung disease characterized by shortness of breath, cough, sputum production, and chronically poor airflow with a forced expiratory volume in 1 second (FEV1) of less than … [A7719] By blocking the M3 muscarinic receptor, umeclidinium inhibits the binding of acetylcholine and thereby opens up the airways by preventing bronchoconstriction.
Mixtures: TRELEGY ELLIPTA INHALATION POWDER 100 MCG/62.5 MCG/25 MCG, TRELEGY ELLİPTA 100 MCG + 62,5 MCG +25 MCG KULLANIMA HAZIR İNHALASYON TOZU, 30 DOZCategories: vilanterol and umeclidinium bromide, Cytochrome P-450 SubstratesMepivacaine
go.drugbank.com/drugs/DB00961ApprovedInvestigationalVet approvedA local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. … Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
Synonyms: 1-methyl-2',6'-pipecoloxylidide, (+-)-1-Methyl-2',6'-pipecoloxylidideMixtures: 2% Polocaine Dental With Levonordefrin 1:20,000, Mepivacaine Hydrochloride and LevonordefrinIpratropium
go.drugbank.com/drugs/DB00332ApprovedInvestigational[A176957] Ipratropium as a therapeutic agent was developed by Boehringer Ingelheim and its first monotherapy product was FDA approved in 1986, while the combination product of ipratropium and [albuterol … [A176939] It is commonly administered through inhalation which allows producing a local effect without presenting a significant systemic absorption.
Mixtures: NASOVİNE DUO 0,5 MG + 0,6 MG/ML BURUN SPREYİ, ÇÖZELTİ, 1 ADET, NOTECORT 20 MCG / 50 MCG AEROSOL İNHALASYONU, ÇÖZELTİ, 1 ADETCategories: fenoterol and ipratropium bromide, salbutamol and ipratropium bromideBetaxolol
go.drugbank.com/drugs/DB00195ApprovedInvestigationalA cardioselective beta-1-adrenergic antagonist with no partial agonist activity.
Categories: Adrenergic beta-1 Receptor Antagonists, Antiglaucoma Preparations and MioticsSynonyms: 1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-((1-methylethyl)amino)-2-propanol, 1-(isopropylamino)-3-[p-(cyclopropylmethoxyethyl)phenoxy]-2-propanolTiotropium
go.drugbank.com/drugs/DB01409ApprovedInvestigational[A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation. … Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma.
Mixtures: SALTIF 9/50/100 MCG INHALASYON IÇIN TOZ IÇEREN BLISTER, 60 DOZ, TROFAS 9/50/100 MCG INHALASYON IÇIN TOZ IÇEREN KAPSÜL, 120 KAPSÜLCategories: olodaterol and tiotropium bromide, formoterol and tiotropium bromideCalfactant
go.drugbank.com/drugs/DB06415ApprovedInvestigationalEach milliliter of calfactant contains 35mg of phospholipids (including 26 mg phosphatidylcholine of which 16 mg is disaturated phosphatidylcholine) and 0.65mg of proteins including surfactant-associated … proteins B and C.
Synonyms: SF-RI 1Products: ALVEOFACT 50 MG/1.2 ML INTRATRAKEAL STERİL APİROJEN SÜSPANSİYON, 1 ADET, INFASURF 35 MG/ML INTRATRAKEAL SÜSPANSIYON ,6 MLFerric derisomaltose
go.drugbank.com/drugs/DB15617ApprovedInvestigational[A190528] Ferric derisomaltose is a form of iron used in the treatment of iron deficiency. This drug is a complex of iron (III) hydroxide and derisomaltose. … Iron deficiency is an extremely common condition and is the most frequent cause of anemia worldwide.
Products: Diafer 50 mg/ml Injektionslösung, MONOFER® SOLUTION FOR INJECTION OR INFUSION 100 MG/MLIbutilide
go.drugbank.com/drugs/DB00308ApprovedIbutilide is a Class III antiarrhythmic agent available in intravenous formulations. … It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR).
Synonyms: N-(4-{4-[ethyl(heptyl)amino]-1-hydroxybutyl}phenyl)methanesulfonamideProducts: Fybrio 1 mg/10 ml I.V. Enjeksiyonluk Çözelti, 1 ADET, Corvert 87 Mikrogramm/ml Infusionslösung