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Beractant

In comparison to synthetic forms of surfacant, natural forms such as Beractant have been found to have a reduced incidence of pneumothorax and reduced mortality. … In anticipation of birth, endogenous lung surfactant is produced to lower the surface tension on alveolar surfaces and to stabilize the alveoli against collapse at resting transpulmonary pressures.

Umbralisib

Unfortunately, many patients experience a relapse or develop resistance to these drugs. … Treatment options then become limited, and alternate treatments for the lymphoma are required to control disease progression.

Pentamidine

Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other t...

Tisotumab vedotin

Tisotumab vedotin targets TF-expressing cells to deliver MMAE to induce direct cytotoxicity and bystander killing of neighboring cells. … Tisotumab vedotin is the first TF-directed ADC [A238914] that works by binding to TFs expressed on solid tumours.

Cloperastine

Cloperastine is a cough suppressant that acts on the central nervous system.

Zoliflodacin

Gonorrhea, caused by Neisseria gonorrhoeae, presents a significant public health challenge due to increasing antimicrobial resistance. … [A275268] Zoliflodacin is a first-in-class spiropyrimidinetrione antibiotic designed to address this need by inhibiting bacterial type II topoisomerases (DNA gyrase and topoisomerase IV), thereby blocking

Poliomyelitis virus type 3 (live, attenuated)

Bunamiodyl

Withdrawn from the Canadian, US, and UK markets in 1963 due to nephropathy.

Dantron

Withdrawn from the Canadian, US, and UK markets in 1998 due to genotoxicity.

Oxeladin

Withdrawn from the Canadian, US, and UK markets in 1976 due to carcinogenicity.