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Canrenoic acid
go.drugbank.com/drugs/DB09015ApprovedInvestigationalWithdrawnLike spironolactone, it is a prodrug, which is metabolized to canrenone in the body.
Categories: Hormones, Hormone Substitutes, and Hormone AntagonistsProducts: Aldactone 200 mg/ 10 ml Injektionslösung, POTASSIO CANRENOATO EGErenumab
go.drugbank.com/drugs/DB14039ApprovedInvestigationalErenumab (AMG-334) (INN; trade name Aimovig) is a human monoclonal antibody designed specifically to bind and antagonize the calcitonin gene-related peptide receptor (CGRPR) as a means to prevent migraines … It is composed of 2 heavy chains, each containing 456 amino acids, and 2 light chains of the lambda subclass, each containing 216 amino acids, with an approximate molecular weight of 150 kDa [FDA Label
Categories: Amino Acids, Peptides, and ProteinsProducts: PASURTA® 140 MG /ML, KUZELVA 70 MG ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR ENJEKTÖR, 1 ADETThiotepa
go.drugbank.com/drugs/DB04572ApprovedInvestigationalN,N'N'-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group, now in use for over 50 years. … It is a stable derivative of N,N',N''- triethylenephosphoramide (TEPA). It is mostly used to treat breast cancer, ovarian cancer and bladder cancer.
Synonyms: Tri-1-aziridinylphosphine sulfide, Tris(1-aziridinyl)phosphine sulfideCategories: Heterocyclic Compounds, 1-Ring, Antineoplastic and Immunomodulating AgentsNabumetone
go.drugbank.com/drugs/DB00461ApprovedNabumetone was developed by Smithkline Beecham under the trade name Relafen and first received FDA approval in December, 1991.[L6568] … [label,A178903] The molecule itself is a pro-drug with its 6-methoxy-2-naphthylacetic acid (6-MNA) metabolite acting as a potent COX inhibitor similar in structure to [naproxen].
Synonyms: 4-(6-Methoxy-2-naphthalenyl)-2-butanone, 4-(6-Methoxy-2-naphthyl)-2-butanoneMixtures: NuDroxiPAK N-500Clotrimazole
go.drugbank.com/drugs/DB00257ApprovedInvestigationalVet approvedAs well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers [A174094]. … This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s [A174094].
Synonyms: 1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole, 1-(o-Chlorotrityl)imidazoleMixtures: Imazol duo 10 mg/g + 2,5 mg/g Creme, MYKOFUNGIN 3 200MG+10MG/GUlipristal
go.drugbank.com/drugs/DB08867ApprovedInvestigationalIt is a derivative of 19-norprogesterone and has both antagonistic and partial agonist activity at the progesterone receptor. … It also binds to glucocorticoid receptor, however compared to mifepristone (a progesterone receptor antagonist), ulipristal is more tolerable and has lower glucocorticoid activity and better binding affinity
Categories: Genito Urinary System and Sex Hormones, Sex Hormones and Modulators of the Genital SystemProducts: ESMYA® 5 MG COMPRIMIDOS, JOSEİ 30 MG TABLET, 1 ADETRifaximin
go.drugbank.com/drugs/DB01220ApprovedInvestigationalsyndrome (IBS-D) in adult women and men. … It has multiple indications and is used in treatment of traveller's diarrhea caused by E. coli; reduction in risk of overt hepatic encephalopathy recurrence; as well as diarrhea-predominant irritable bowel
Synonyms: Rifamycin L 105, Rifamycin L 105SVCategories: Alimentary Tract and Metabolism, Cytochrome P-450 SubstratesFluvastatin
go.drugbank.com/drugs/DB01095ApprovedInvestigationalFluvastatin is a racemate comprising equimolar amounts of (3R,5S)- and (3S,5R)-fluvastatin. … Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase.
Categories: Cytochrome P-450 CYP2B6 Inducers, Cytochrome P-450 CYP1A1 SubstratesProducts: Lescol MR 80 mg - Filmtabletten, LESCOL XL TABLET 80 mgBupropion
go.drugbank.com/drugs/DB01156ApprovedInvestigationalPOMC auto-inhibition, which are associated with a reduction in food intake and increased energy expenditure. … [L6562,A179038,A179050] The combination of naltrexone and bupropion was shown to result in a statistically significant weight loss, with a mean change in body weight of -6.3% compared to -1.3% for placebo
Mixtures: Appbutamone-D, Naltrexone Hydrochloride and Bupropion Hydrochloride Extended-ReleaseCategories: bupropion and naltrexone, bupropion and dextromethorphanGuselkumab
go.drugbank.com/drugs/DB11834ApprovedInvestigationalIn clinical trials, guselkumab demonstrated improved skin clearance and symptomatic improvements in dermatological manifestations of psoriasis. … Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin-23.
Categories: Amino Acids, Peptides, and Proteins, Skin and Mucous Membrane AgentsProducts: TREMFYA 100 MG/ML ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR KALEM, 1 ADET, TREMFYA 100 MG/ML ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR ENJEKTÖR, 1 ADET