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Displaying results 2911 - 2920 of 10000 in total
  1. Drug

    Sacituzumab govitecan

    go.drugbank.com/drugs/DB12893
    ApprovedInvestigational

    [A193671] One such ADC is sacituzumab govitecan, which combines a humanized anti-trophoblast cell-surface antigen 2 (TROP-2) antibody with the topoisomerase I inhibitor SN-38. … [A193653] In November 2021 and July 20 2023, sacituzumab govitecan was also approved by the European Commission and Health Canada respectively.[L39372,L47601]

    Categories: Trop-2-Directed Monoclonal AntibodiesProducts: TRODELVY 200 MG İNFÜZYONLUK ÇÖZELTİ KONSANTRESİ İÇİN TOZ, 1 ADET, TRODELVY®
  2. Drug

    Telaprevir

    go.drugbank.com/drugs/DB05521
    ApprovedWithdrawn

    HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, and affecting 72% of all chronic HCV patients [L852]. … Treatment options for chronic Hepatitis C have advanced significantly since 2011, with the development of Direct Acting Antivirals (DAAs) such as Telaprevir.

    Categories: P-glycoprotein inhibitors, P-glycoprotein substratesSynonyms: (1S,3aR,6aS)-(2S)-2-cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-((1S)-1-((cyclopropylamino)oxoacetyl)butyl)octahydrocyclopenta(c)pyrrole-1-carboxamide
  3. Drug

    Nitrofural

    go.drugbank.com/drugs/DB00336
    ApprovedVet approvedWithdrawn

    Nitrofural has also been administered orally in the treatment of trypanosomiasis. … Nitrofural or nitrofurazone is a topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial wounds, burns, ulcers, and skin infections.

    Mixtures: MADECASSOL CCategories: Heterocyclic Compounds, 1-Ring
  4. Drug

    Clomifene

    go.drugbank.com/drugs/DB00882
    ApprovedInvestigational

    A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue.

    Categories: P-glycoprotein substratesSynonyms: 2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethylethanamine, 2-(p-(2-chloro-1,2-diphenylvinyl)phenoxy)triethylamine
  5. Drug

    Ethynodiol diacetate

    go.drugbank.com/drugs/DB00823
    Approved

    A synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive. … Although etynodiol or ethynodiol are sometimes used as a synonym for ethynodiol diacetate, what is usually being referred to is actually ethynodiol diacetate and not ethynodiol (which is a separate drug

    Mixtures: Kelnor 1/35, Zovia 1/35Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  6. Drug

    Diacerein

    go.drugbank.com/drugs/DB11994
    ApprovedInvestigationalWithdrawn

    Diacerein is under investigation for the treatment of Insulin Resistance, Diabetes Mellitus (Type 2), and Diabetes-Related Complications. … Diacerein is a prodrug which is metabolized to rhein.

    Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP2C9 InhibitorsProducts: ARTRIDOX®50 MG CAPSULAS, ARTRO - M CAPSULAS
  7. Drug

    Manganese cation

    go.drugbank.com/drugs/DB06757
    ApprovedInvestigationalNutraceutical

    Manganese is a transition metal that was first described in the 19th and 20th centuries. … [A263687, A263662] In humans, manganese regulates several physiological processes by acting as a cofactor for proteins [A263657, A263662, A263667] making it an essential metal for normal development and

    Mixtures: Calcium With Mg Zn Mn Cu CR Si and Vit. C & D, Prim - Royal P.M.T.Synonyms: MANGANESE(2+), MANGANESE ION(2+)
  8. Drug

    Ferrous sulfate anhydrous

    go.drugbank.com/drugs/DB13257
    ApprovedInvestigational

    [A190528] Ferrous sulfate is a synthetic agent used in the treatment of iron deficiency. It is the gold standard of oral iron therapy in the UK and many other countries.[L2234,L2246] … Iron deficiency anemia is a large public health concern worldwide, especially in young children, infants, and women of childbearing age.

    Mixtures: Exact-Rx SODIUM SULFACETAMIDE and SULFER 10%/5% Cleanser, Ferrograd - Fol 105 mg / 0,35 mg FilmtablettenSynonyms: iron(2+) sulfate (anhydrous), iron sulfate (1:1)
  9. Drug

    Alectinib

    go.drugbank.com/drugs/DB11363
    ApprovedInvestigational

    It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes proliferation of NSCLC … Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase.

    Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
  10. Drug

    Racementhol

    go.drugbank.com/drugs/DB14123
    ApprovedInvestigational

    Mixtures: Dfs 1.5%/ms 25%/menth 6%/cap 0.025% Pak, DFS 75mg DR/MS 25%/MENTH 6%/CAP 0.025% PAKSynonyms: (1R,2S,5R)-Menthol, p-Menthan-3-ol