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Displaying results 2921 - 2930 of 10000 in total
  1. Drug

    Lumacaftor

    go.drugbank.com/drugs/DB09280
    ApprovedInvestigational

    improvement of at least 5%. … The most common mutation, affecting approximately 70% of patients with CF worldwide, is known as F508del-CFTR, or delta-F508 (ΔF508), in which a deletion in the amino acid phenylalanine at position 508

    Categories: Cytochrome P-450 CYP2B6 Inducers, Cytochrome P-450 CYP2C19 InducersSynonyms: 3-(6-{[1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropane-1-carbonyl]amino}-3-methylpyridin-2-yl)benzoic acid
  2. Drug

    Difelikefalin

    go.drugbank.com/drugs/DB11938
    ApprovedInvestigational

    Pruritus associated with chronic kidney disease (also called uremic pruritus) affects 50-60% of all patients on dialysis and 25% of non-dialysis patients with chronic kidney disease. … [L36420,L36395] Difelikefalin was later approved by the EMA in April 2022 for the same indication.[L41665]

  3. Drug

    Ruscogenin

    go.drugbank.com/drugs/DB15830
    Investigational

    Mixtures: RECBUTIN 120 MG/10 MG SUPOZITUVAR, 10 ADET, PROCTOLOG SUPOZITUAR, 10 ADET
  4. Target

    Potassium voltage-gated channel subfamily A member 10

    go.drugbank.com/bio_entities/BE0004720
    TargetHumans

    Voltage-gated potassium ion channel that mediates K(+) permeability of excitable membranes. When opened in response to the voltage difference across the membrane, KCNA10 channel selectively allows the flow of potassium ions across the me...

    Polypeptides: Potassium voltage-gated channel subfamily A member 10
  5. Target

    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

    go.drugbank.com/bio_entities/BE0000245
    TargetHumans

    Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of e...

    Polypeptides: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
  6. Target

    ATP-binding cassette sub-family C member 10

    go.drugbank.com/bio_entities/BE0003651
    TransporterHumans

    ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates s...

    Polypeptides: ATP-binding cassette sub-family C member 10
  7. Drug

    Nipocalimab

    go.drugbank.com/drugs/DB16257
    ApprovedInvestigational

    [L64042] It is an aglycosylated, fully human IgG1 monoclonal antibody that binds FcRn and blocks the receptor's recycling of immunoglobulin G (IgG), thereby lowering circulating IgG levels, including pathogenic … [L64042] Nipocalimab-aahu was first approved by the FDA in April 2025 for generalized myasthenia gravis.

  8. Drug

    MGN-4893

    go.drugbank.com/drugs/DB17338
    Experimental

    MGN-4893 is an inhibitor of microRNA-451. In February 2011, it was granted FDA orphan designation for the treatment of polycythemia vera.[L47356]

    Synonyms: MGN 4893
  9. Drug

    Besilesomab

    go.drugbank.com/drugs/DB13979
    Approved

    Utilised only as a diagnostic agent, besilesomab is currently approved by the EMEA for marketing and use in various European countries like Italy, France, Germany, Spain, Portugal, Norway, Sweden, the

  10. Drug

    AMG 424

    go.drugbank.com/drugs/DB17357
    Investigational

    AMG 424 is a novel, humanized, anti-CD3/CD38 bispecific monoclonal antibody being investigated for multiple myeloma.

    Synonyms: AMG-424