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Displaying results 2921 - 2930 of 10000 in total
  1. Drug

    Diethylstilbestrol

    go.drugbank.com/drugs/DB00255
    ApprovedWithdrawn

    A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. … According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen.

    Synonyms: (E)-3,4-bis(4-hydroxyphenyl)-3-hexene, α,α'-diethyl-(E)-4,4'-stilbenediolCategories: P-glycoprotein substrates, Cytochrome P-450 Substrates
  2. Drug

    Isoquinoline, 7-(2-(3,6-dihydro-4-(3-(trifluoromethyl)phenyl)-1(2h)-pyridinyl)ethyl)-

    go.drugbank.com/drugs/DB16204
    Investigational

    Isoquinoline, 7-(2-(3,6-dihydro-4-(3-(trifluoromethyl)phenyl)-1(2h)-pyridinyl)ethyl)- is under investigation in clinical trial NCT00545454 (Activity and Safety of Oral Administration of SSR150106XB for … the Reduction of Inflammation in Patients With Active Rheumatoid Arthritis).

  3. Drug

    PXS-5505

    go.drugbank.com/drugs/DB17510
    Investigational

    Synonyms: 2-buten-1-amine, 3-fluoro-4-(8-quinolinylsulfonyl)-, (2z)-
  4. Drug

    Zardaverine

    go.drugbank.com/drugs/DB02918
    Experimental

    Synonyms: 6-(4-(Difluoromethoxy)-3-methoxyphenyl)-3(2H)-pyridazinoneCategories: Heterocyclic Compounds, 1-Ring
  5. Drug

    Cefotiam

    go.drugbank.com/drugs/DB00229
    Approved

    One of the cephalosporins that has a broad spectrum of activity against both gram-positive and gram-negative microorganisms.

    Synonyms: (6R,7R)-7-[2-(2-Amino-thiazol-4-yl)-acetylamino]-3-[1-(2-dimethylamino-ethyl)-1H-tetrazol-5-ylsulfanylmethyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acidCategories: Heterocyclic Compounds, 2-Ring
  6. Drug

    LCL-161

    go.drugbank.com/drugs/DB12085
    Investigational

    LCL161 has been used in trials studying the treatment of Leukemia, Neoplasms, Solid Tumors, Breast Cancer, and Ovarian Cancer, among others.

    Synonyms: (2S)-N-[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxoethyl]-2-(methylamino)propanamideCategories: Proto-Oncogene Proteins c-bcl-2, antagonists & inhibitors, Heterocyclic Compounds, 1-Ring
  7. Drug

    Captodiame

    go.drugbank.com/drugs/DB09014
    Experimental

    Captodiame, also known as captodiamine, is an antihistamine which is used as a sedative and anxiolytic. It is a derivative of diphenhydramine. … Captodiame has been suggested for use in preventing benzodiazepine withdrawal syndrome.

    Synonyms: 2-[(4-butylsulfanylphenyl)-phenyl-methyl]sulfanyl-N,N-dimethylethanamineCategories: Serotonin 5-HT2 Receptor Antagonists, Serotonin 5-HT2C Receptor Antagonists
  8. Drug

    PLX51107

    go.drugbank.com/drugs/DB17543
    Investigational

    PLX51107 is a potent and selective inhibitor of the bromodomain and extraterminal (BET) protein family. … [A257246,A257251] PLX51107 is under investigation in clinical trial NCT04022785 (PLX51107 and Azacitidine in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome).

    Synonyms: Benzoic acid, 4-(6-(3,5-dimethyl-4-isoxazolyl)-1-((1s)-1-(2-pyridinyl)ethyl)-1h-pyrrolo(3,2-b)pyridin-3-yl)-Categories: Heterocyclic Compounds, 1-Ring
  9. Drug

    (2R)-2-[(1R)-1-{[(2S)-2-Carboxy-2-(4-hydroxyphenyl)acetyl]amino}-1-methoxy-2-oxoethyl]-5-methylene-5,6-dihydro-2H-1,3-oxazine-4-carboxylic acid

    go.drugbank.com/drugs/DB02588
    Experimental

    Synonyms: (2R)-2-[(1R)-1-{[(2S)-2-Carboxy-2-(4-hydroxyphenyl)acetyl]amino}-1-methoxy-2-oxoethyl]-5-methylene-5,6-dihydro-2H-1,3-oxazine-4-carboxylic acid
  10. Drug

    TPCA-1

    go.drugbank.com/drugs/DB17058
    Experimental

    TPCA-1 is a selective inhibitor of human IκB kinase 2 (IKK-2).[A253152]

    Synonyms: 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide, 3-thiophenecarboxamide, 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-Categories: Heterocyclic Compounds, 1-Ring