Captodiame

DB09014ExperimentalSmall molecule

Captodiame, also known as captodiamine, is an antihistamine which is used as a sedative and anxiolytic. It is a derivative of diphenhydramine. Captodiame has been suggested for use in preventing...

Mechanism: Pharmacologically active on 5-hydroxytryptamine receptor 2C, Sigma non-opioid intracellular receptor 1, and Dopamine receptor D3
Curator reviewed
Primary indication: Captodiame is indicated for the treatment of anxiety.Curator reviewed
Formula / weight: C₂₁H₂₉NS₂ · 359.592 g/mol (avg)
Code names: AY 55074 · N 68

Resolves to

Compound

UNIIH93K9455DDCAS486-17-9ChEMBLCHEMBL2110809ChEBI135521PubChem10240KEGGD07316

Clinical / RWD

RxNorm89812ATCN05BB02

Structure

InChIKeyIZLPZXSZLLELBJ-UHFFFAOYSA-NSMILESCCCCSC1=CC=C(C=C1)C(SCCN(C)C)C1=CC=CC=C1

Targets

P28335HTR2CQ99720SIGMAR1P35462DRD3

What you can answer from here — as of August 30, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

681Drug interactionsStructured to mechanism, not free text

1ATC codeIncluding every combination product, plus 10 drug categories

6+ReferencesStructured and connected to the statements they support

Which drugs share a target with Captodiame, and which of those have an active Phase 3 trial?

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