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Rindopepimut
go.drugbank.com/drugs/DB05374InvestigationalThe US FDA granted it Breakthrough Therapy Designation for glioblastoma in Feb 2015.
Cortisone
go.drugbank.com/drugs/DB14681InvestigationalIt is converted in the liver to the active metabolite hydrocortisone. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726) … It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive.
Synonyms: Kendall's compound E, pregn-4-en-17α,21-diol-3,11,20-trioneCositecan
go.drugbank.com/drugs/DB05806InvestigationalIt has been developed for superior oral bioavailability and increased lactone stability. It is used to treat cancer.
Glisoxepide
go.drugbank.com/drugs/DB01289InvestigationalIt inhibits the uptake of bile acids into isolated rat hepatocytes. However it inhibits taurocholate uptake only in the absence of sodium ions.
Nigericin
go.drugbank.com/drugs/DB14056ExperimentalIt is produced by Streptomyces hygroscopicus. (From Merck Index, 11th ed)
Carbocromen
go.drugbank.com/drugs/DB13279ApprovedWithdrawnCarbocromen was marketed for use in Germany as a vasodilator, however, it has been discontinued due to the risk of arrhythmia development [L5635].
Tetraethylammonium
go.drugbank.com/drugs/DB08837InvestigationalBecause of its inhibitory actions at the autonomic ganglia, tetraethylammonium was thought to be a potential therapeutic vasodilator but serious toxic effects were found. … Its mechanism of action is still being investigated, but it is known that tetraethylammonium blocks autonomic ganglia, calcium- and voltage- activated potassium channels, and nicotinic acetylcholine receptors