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Verubecestat
go.drugbank.com/drugs/DB12285InvestigationalIn the study, administration of Verubecestat at doses of 12, 40 and 60 mg resulted in a dose-dependent and sustained reduction in the levels of Ab40, a measure of BACE1 activity, in CSF from baseline of … 57, 79 and 84 percent, respectively.
Nicoboxil
go.drugbank.com/drugs/DB12911ApprovedWithdrawnnicoboxil/nonivamide topical analgesic medication being used since the 1950s, recent studies demonstrate continued interest in the medication(s) given its demonstrated efficacy, safety, and capability to … be used as an alternative musculoskeletal pain therapy option with less systemic side effects when compared to the oral non-steroidal anti-inflammatory drugs and opioids that may be more typically prescribed
Mixtures: Nonivamid + Nicoboxil Zentiva 4 mg/g + 25 mg/g SalbeNorgestrel
go.drugbank.com/drugs/DB09389ApprovedNorgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer ([levonorgestrel]) is biologically active.
Mixtures: CYCLO-PROGYNOVA 2 MG+2 MG/0.5 MG KAPLI TABLET, 21 ADET, Lo/OvralCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesAscaris Infection
go.drugbank.com/conditions/DBCOND0125533Drugs: IvermectinSynonyms: Disease due to Nematoda (disorder)Chronic renal failure anemia
go.drugbank.com/conditions/DBCOND0089208Drugs: Nandrolone decanoateSynonyms: Anaemia secondary to chronic renal failureInfluenza A Virus Infection
go.drugbank.com/conditions/DBCOND0036858Drugs: Amantadine · Influenza A virus A/Hong Kong/4801/2014 (H3N2) recombinant hemagglutinin antigen · Influenza A virus A/Hong Kong/4801/2014 X-263B (H3N2) antigen (propiolactone inactivated) · Influenza A virus A/Michigan/45/2015 (H1N1) recombinant hemagglutinin antigen · Influenza A virus A/New caledonia/71/2014 (H3N2) live (attenuated) antigen · Influenza A virus A/Singapore/GP1908/2015 IVR-180A (H1N1) antigen (propiolactone inactivated) +3 moreSynonyms: Influenza due to unidentified influenza virus with other respiratory manifestationsAprocitentan
go.drugbank.com/drugs/DB15059ApprovedInvestigationalApproximately 10-15% of patients with hypertension have resistant hypertension, defined as uncontrolled high blood pressure despite the combined use of a renin-angiotensin system blocker, a calcium channel … [L50261] It was the first antihypertensive employing a novel mechanism to be approved in almost 40 years.[L50261]
Categories: Cytochrome P-450 CYP2C18 Inhibitors, Cytochrome P-450 CYP3A InducersStannous fluoride
go.drugbank.com/drugs/DB11092ApprovedInvestigationalAlthough similar in function and activity to Sodium Fluoride (NaF), the conventionally added ingredient in toothpastes, stannous fluoride has been shown to be more effective at stopping and reversing dental … Stannous Fluoride, or Tn(II) Fluoride, is a compound commonly used in toothpastes for the prevention of gingivitis, dental infections, cavities, and to relieve dental hypersensitivity.
Products: DG Health Restore and Defend Sensitive, Complete Protection TPIvosidenib
go.drugbank.com/drugs/DB14568ApprovedInvestigationalIDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. … [L46287] It was fully approved by the EMA in May 2023.[L46596]
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InducersCCX915
go.drugbank.com/drugs/DB05159ExperimentalThe CCR2 receptor is thought to be of central importance to inflammatory diseases, such as multiple sclerosis (MS), Type II diabetes and atherosclerosis. … CCX915 is developed by ChemoCentryx which targets the chemokine receptor CCR2 and is in phase 1 of clinical trial for the treatment of Multiple Sclerosis and Neurologic Disorders.