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Displaying results 2981 - 2990 of 10000 in total
  1. Drug

    Bromfenac

    go.drugbank.com/drugs/DB00963
    ApprovedWithdrawn

    Non-ophthalmic formulations of bromfenac were withdrawn in the US in 1998 due to cases of severe liver toxicity.[L43942,T239] … Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation.

    Categories: Selective Cyclooxygenase 2 Inhibitors (NSAIDs)Synonyms: [2-Amino-3-(4-bromo-benzoyl)-phenyl]-acetic acid, 2-amino-3-(4-bromobenzoyl)benzeneacetic acid
  2. Drug

    Crovalimab

    go.drugbank.com/drugs/DB16128
    ApprovedInvestigational

    [L50933] Unlike other complement inhibitors previously approved for PNH, crovalimab uses a mechanism called anti-C5 sequential monoclonal antibody recycling technology that allows the drug to bind to … [A263958] It soon gained its approval in Japan in the next month,[A263958] and in the USA in June of the same year.

    Synonyms: IGHJ4*01 (100%)) (9.8.15) (1-123)-HOMO SAPIENS IGHG1*, IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS C5 (COMPLEMENT 5)), MONOCLONAL ANTIBODYGAMMA1 HEAVY CHAIN (1-451) (VH (VICUGNA PACOS IGHV3S1*01 (70.4%)/HOMO SAPIENS IGHV3-66*01 (69.4%)-(IGHD)-HOMO SAPIENS
  3. Drug

    Methyl aminolevulinate

    go.drugbank.com/drugs/DB00992
    ApprovedInvestigational

    Methyl aminolevulinate is a prodrug that is metabolised to Protoporphyrin IX (a photosensitizer) used in photodynamic therapy.

    Synonyms: Aminolevulinato de metilo, methyl 5-aminolevulinateProducts: METVIX® CREMA 160 MG/G, Metvix 160mg/g Cream
  4. Drug

    Relacorilant

    go.drugbank.com/drugs/DB14976
    ApprovedInvestigational

    Originally investigated to manage the metabolic and endocrinologic complications of hypercortisolism, such as Cushing’s syndrome, its clinical utility has pivoted toward oncology as a potent sensitizing … in the context of resistant cancers.

    Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 CYP2C8 Inducers
  5. Drug

    Pirenzepine

    go.drugbank.com/drugs/DB00670
    ApprovedWithdrawn

    It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. … It also potentiates the effect of other antiulcer agents such as cimetidine and ranitidine. It is generally well tolerated by patients.

    Categories: Heterocyclic Compounds, 2-RingSynonyms: 11-((4-Methyl-1-piperazinyl)acetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one
  6. Drug

    Ifosfamide

    go.drugbank.com/drugs/DB01181
    ApprovedInvestigational

    Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent.

    Categories: Cytochrome P-450 CYP2A6 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2B6 Substrates with a Narrow Therapeutic IndexSynonyms: 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
  7. Drug

    Mangafodipir

    go.drugbank.com/drugs/DB06796
    ApprovedInvestigationalWithdrawn

    The contrast agent is present as mangafodipir trisodium marketed under the name Teslascan. … Mangafodipir is a contrast agent used as a diagnostic tool administered intravenously to enhance contrast in magnetic resonance imaging (MRI) of the liver and pancreas.

    Categories: Heterocyclic Compounds, 1-Ring, Compounds used in a research, industrial, or household settingProducts: TESLASCAN 0,01MMOL 50 ML FLAKON, 1 ADET
  8. Drug

    Soy isoflavones

    go.drugbank.com/drugs/DB14101
    Approved

    Mixtures: D-Cal SoyCal, ISOFLAVONA DE SOYA + VITAMINA D300 UI +CITRATO DE CALCIO.Products: FITOFLAVONA® 35 MG, APROLAC® 80 MGTABLETAS
  9. Drug

    Dimethyl fumarate

    go.drugbank.com/drugs/DB08908
    ApprovedInvestigational

    It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated … Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.

    Synonyms: (E)-But-2-enedioic acid dimethyl esterProducts: D-FUMARIC 240 CAPSULAS DE LIBERACIÓN RETARDADA 240 MG, D-FUMARIC 120 CAPSULAS DE LIBERACION RETARDADA 120 MG
  10. Drug

    Ecallantide

    go.drugbank.com/drugs/DB05311
    Approved

    The protease plasma kallikerin facilitates the conversion of kininogen to bradykinin, which is a pro-inflammatory vasodilator that increases vascular permeability and induces pain [A3362]. … The disorder is associated with recurrent attacks of severe swelling and is thought to be caused by unregulated activity of kallikrein and excessive bradykinin production [FDA Label].

    Products: KALBITOR® 10 MG / ML