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Posaconazole Action Pathway
smpdb.ca/view/SMP0125831Drug actionPosaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. For prophylaxis of invasive Aspergillus and Candida infections in pat...
Sertaconazole Action Pathway
smpdb.ca/view/SMP0125419Drug actionSertaconazole might also inhibit endogenous respiration, interact with membrane phospholipids, inhibit transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or
Isoconazole Action Pathway
smpdb.ca/view/SMP0125819Drug actionIsoconazole is an imidazole antifungal used for superficial skin and vaginal infections. Isoconazole, like other imidazole antifungals, inhibits lanosterol 14-alpha demethylase in the endoplasmic reticulum of fungal cells. Lanosterol 14-...
Bifonazole Action Pathway
smpdb.ca/view/SMP0125418Drug actionBifonazole is an azole anti-fungal drug used to treat fungal skin infections, such as dermatomycosis and athlete's foot. It comes as a cream which is spread on the infected skin. Bifonazole inhibits lanosterol 14-alpha demethylase in the...
Butoconazole Action Pathway
smpdb.ca/view/SMP0125812Drug actionButoconazole is an imidazole antifungal used to treat vulvovaginal candidiasis. The exact mechanism of the antifungal action of butoconazole is unknown, however, it is presumed to function as other imidazole derivatives via inhibition of...
Efinaconazole Action Pathway
smpdb.ca/view/SMP0125813Drug actionEfinaconazole is an antifungal agent used to treat onychomycosis, a fungal infection of the nail. Efinaconazole inhibits lanosterol 14-alpha demethylase in the endoplasmic reticulum of fungal cells. Lanosterol 14-alpha demethylase is the...
Isavuconazole Action Pathway
smpdb.ca/view/SMP0125814Drug actionIsavuconazole is an triazole antifungal. It works by inhibiting fungal cell membrane synthesis. Invasive fungal infections pose significant clinical challenges for patients, especially those who are immunocompromised. In vitro, most of t...
Isavuconazonium Action Pathway
smpdb.ca/view/SMP0125818Drug actionIsavuconazonium is a second-generation triazole antifungal which is used to treat invasive aspergillosis and invasive mucormycosis. Due to low solubility in water of isavuconazole on its own, the isovuconazonium formulation is favorable ...
Oteseconazole Action Pathway
smpdb.ca/view/SMP0125830Drug actionOteseconazole is an azole antifungal used to prevent recurrent vulvovaginal candidiasis in females who are not of reproductive potential. By binding and inhibiting CYP51, oteseconazole is active against most microorganisms associated wit...
Sulconazole Action Pathway
smpdb.ca/view/SMP0125832Drug actionSulconazole is a topical antifungal agent used for the treatment of tinea cruris, tinea corporis, and tinea versicolor caused by susceptible fungal strains. It is known by the brand name Exelderm available as a topical cream and solution...