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Efinaconazole Action Pathway
smpdb.ca/view/SMP0125813Drug actionEfinaconazole is an antifungal agent used to treat onychomycosis, a fungal infection of the nail. Efinaconazole inhibits lanosterol 14-alpha demethylase in the endoplasmic reticulum of fungal cells. Lanosterol 14-alpha demethylase is the...
Isavuconazole Action Pathway
smpdb.ca/view/SMP0125814Drug actionIsavuconazole is an triazole antifungal. It works by inhibiting fungal cell membrane synthesis. Invasive fungal infections pose significant clinical challenges for patients, especially those who are immunocompromised. In vitro, most of t...
Isavuconazonium Action Pathway
smpdb.ca/view/SMP0125818Drug actionIsavuconazonium is a second-generation triazole antifungal which is used to treat invasive aspergillosis and invasive mucormycosis. Due to low solubility in water of isavuconazole on its own, the isovuconazonium formulation is favorable ...
Oteseconazole Action Pathway
smpdb.ca/view/SMP0125830Drug actionOteseconazole is an azole antifungal used to prevent recurrent vulvovaginal candidiasis in females who are not of reproductive potential. By binding and inhibiting CYP51, oteseconazole is active against most microorganisms associated wit...
Sulconazole Action Pathway
smpdb.ca/view/SMP0125832Drug actionSulconazole is a topical antifungal agent used for the treatment of tinea cruris, tinea corporis, and tinea versicolor caused by susceptible fungal strains. It is known by the brand name Exelderm available as a topical cream and solution...
Segawa Syndrome
smpdb.ca/view/SMP0000490DiseaseTetrahydrobiopterin is an important compound in the production of neurotransmitters, specifically dopamine and serotonin, and the processing of quite a few amino acids, The mutation on GCH1 causes GTP
DOPA-Responsive Dystonia
smpdb.ca/view/SMP0000486DiseaseTetrahydrobiopterin is an important compound in the production of neurotransmitters, specifically dopamine and serotonin, and the processing of quite a few amino acids, The mutation on GCH1 causes GTP
Hyperphenylalaninemia Due to DHPR-Deficiency
smpdb.ca/view/SMP0000489DiseaseWhen tetrahydrobiopterin levels drop, the breakdown of many several amino acids, such as phenylalanine, is reduced and as a result their levels in the blood augment.
DOPA-Responsive Dystonia
smpdb.ca/view/SMP0125582DiseaseTetrahydrobiopterin is an important compound in the production of neurotransmitters, specifically dopamine and serotonin, and the processing of quite a few amino acids, The mutation on GCH1 causes GTP
Clotrimazole Action Pathway
smpdb.ca/view/SMP0125104Drug actionacids. … The Hydroxycarboxylic acid receptor has a high affinity for (D)-beta-hydroxybutyrate and nicotinic acid, but only in high enough doses that are not present in the human body.
Drugs: ATP · Clotrimazole · Magnesium cation · Formic acid · Cyclic adenosine monophosphate · Mesoheme +1 moreEnzymes: Hydroxycarboxylic acid receptor 2