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Aprocitentan
go.drugbank.com/drugs/DB15059ApprovedInvestigationalEndothelin receptor antagonism provides a novel therapeutic pathway for the management of patients with resistant hypertension. … [L50261] It was the first antihypertensive employing a novel mechanism to be approved in almost 40 years.[L50261]
Categories: Endothelin Receptor AntagonistsPatent Blue
go.drugbank.com/drugs/DB13967ApprovedInvestigational[L1113] The isomer isosulphan is used in the United States for the same indications than patent blue.[A32574] … Patent blue is aniline dye and it is one of the most common dyes used.[A32573] It is a sodium or calcium salt of diethylammonium hydroxide inner salt.
Trastuzumab deruxtecan
go.drugbank.com/drugs/DB14962ApprovedInvestigationalThe cleavable peptide linker used to bind the antibody and drug in this product distinguishes it from other members of its class. … [A188988] Trastuzumab deruxtecan was developed by Daiichi Sankyo in collaboration with AstraZeneca and was first approved by the FDA in 2019.[L10842]
Synonyms: T-DXd, T- DXdCategories: HER2 Receptor Antagonists, HER2 (Human Epidermal Growth Factor Receptor 2) inhibitorsQuinagolide
go.drugbank.com/drugs/DB09097ApprovedWithdrawnQuinagolide is a non-ergot-derived selective dopamine D2 receptor agonist used for the treatment of elevated levels of prolactin or hyperprolactinaemia. … Newer dopamine receptor agonists such as quinagolide and [DB00248] are shown to effectively inhibit prolactin secretion with improved efficacy over [DB01200].
Categories: Dopamine D2 Receptor AgonistsSacubitril
go.drugbank.com/drugs/DB09292ApprovedInvestigationalIt was approved by the FDA after being given the status of priority review for on July 7, 2015. … Sacubitril is a prodrug neprilysin inhibitor used in combination with valsartan to reduce the risk of cardiovascular events in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection
Tranexamic acid
go.drugbank.com/drugs/DB00302ApprovedInvestigationalIt possesses a similar mechanism of action to [aminocaproic acid] but is approximately 10-fold more potent. … Tranexamic acid is a synthetic derivative of [lysine] used as an antifibrinolytic in the treatment and prevention of major bleeding.
Products: ZYEX-T, HEAMIC-T (Tranexamic Acid Injection 100mg/mL)Cinacalcet
go.drugbank.com/drugs/DB01012ApprovedInvestigationalIt is used to treat hyperparathyroidism due to parathyroid tumours or renal failure. … Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe.
Categories: Calcium-sensing Receptor Agonist, Increased Calcium-sensing Receptor SensitivityRofecoxib
go.drugbank.com/drugs/DB00533ApprovedWithdrawnStilbenes (C6-C2-C6 ) are derived from the common phenylpropene (C6-C3) skeleton building block. The introduction of one or more hydroxyl groups to a phenyl ring lead to stilbenoids. … This compound belongs to the stilbenes. These are organic compounds containing a 1,2-diphenylethylene moiety.
Nandrolone decanoate
go.drugbank.com/drugs/DB08804ApprovedIllicitInvestigationaleffect compared to nandrolone and other esters. … Nandrolone decanoate, also known as nandrolone caprinate, is an alkylated anabolic steroid indicated in the management of anemia of renal insufficiency and as an adjunct therapy in the treatment of senile
Molindone
go.drugbank.com/drugs/DB01618ApprovedAn indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. … It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors.
Categories: Dopamine D2 Receptor Antagonists, Serotonin Receptor Antagonists