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Tremelimumab
go.drugbank.com/drugs/DB11771ApprovedInvestigational[A253717] By binding to CTLA-4, tremelimumab enhances T cell-mediated killing of tumours and reduces tumour growth. … [L43652] It is also being investigated in other cancers, such as colon cancer, pancreatic cancer, non-small cell lung cancer (NSCLC), and malignant melanoma.
Categories: CTLA-4-directed Blocking Antibody, Amino Acids, Peptides, and ProteinsProducts: Imjudo 300 mg/15 ml İnfüzyonluk Çözelti Hazırlamak İçin Konsantre, 1 adet, Imjudo 25 mg/1.25 mL İnfüzyonluk Çözelti Hazırlamak İçin Konsantre, 1 adetCysteamine
go.drugbank.com/drugs/DB00847ApprovedInvestigational[L15606] Cysteamine eye drops are a practical and effective option for those affected by ocular cystinosis. … A defect in cystinosin function is followed by cystine accumulation throughout the body, especially the eyes and kidneys.
Categories: Amino Acids and Derivatives, Alimentary Tract and MetabolismSynonyms: 2-amino-1-ethanethiol, β-MEASatralizumab
go.drugbank.com/drugs/DB15762ApprovedInvestigationalSatralizumab is a recombinant humanized monoclonal antibody targeted against human interleukin-6 (IL-6) receptors, similar to [tocilizumab], which is produced in Chinese hamster ovary cells and based on … Enspryng®, a satralizumab formulation developed by Chugai Pharmaceutical and Roche,[L15536] is uniquely formulated with "recycling antibody technology" whereby the association of satralizumab to IL-6 receptors
Categories: Interleukin-6 Receptor Antagonist, Amino Acids, Peptides, and ProteinsSynonyms: Humanised anti-IL-6 receptor monoclonal antibodyRemlarsen
go.drugbank.com/drugs/DB19131InvestigationalRemlarsen is under investigation in clinical trial NCT03601052 (Efficacy, Safety, and Tolerability of Remlarsen (MRG-201) Following Intradermal Injection in Subjects With a History of Keloids).
Synonyms: -cholest-5-en-3-yloxy)hexyl)oxy)-2-hydroxypropyl hydrogen phosphate), complex with rna ((2'-deoxy-2'-fluoro)u-a-g-(2'-deoxy-2'-fluoro)c-a-(2'-deoxy-2'-fluoro)c-(2'-de, Rna, (am-am-cm-a-cm-um-g-um-um-um-a-cm-a-a-a-um-g-g-um-cm-cm-um-a), 3'-(3-((6-((3.beta.)Zilucoplan
go.drugbank.com/drugs/DB15636ApprovedInvestigationalZilucoplan is a 15 amino-acid, synthetic macrocyclic peptide. … [A261841] On October 17, 2023, zilucoplan gained its first FDA approval for the treatment of generalized myasthenia gravis.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsSynonyms: .-(2-(((4S)-4-CARBOXY-1-OXO-4-(1-OXOHEXADECYL)BUTYL)AMINO)ETHYL)-.OMEGA.-HYDROXY-, 15-ETHER WITH N-ACETYL-L-LYSYL-L-VALYL-L-.ALPHA.-GLUTAMYL-L-ARGINYL-L-PHENYLALANYL-L-.ALPHA., N2-ACETYL-L-LYSYL-L-VALYL-L-.ALPHA.-GLUTAMYL-L-ARGINYL-L-PHENYLALANYL-L-.ALPHA.-ASPARTYL-N-METHYL-L-.ALPHA.-ASPARTYL-3-METHYL-L-VALYL-L-TYROSYL-3-(1H-PYRROLO(2,3-B)PYRIDIN-3-YL)-L-ALANYL-L-.ALPHA.Ofatumumab
go.drugbank.com/drugs/DB06650ApprovedInvestigational[L12612] Although it has a similar molecular mechanism of action as [rituximab], another CD-20 monoclonal antibody used in the treatment of rheumatoid arthritis and B-cell non-Hodgkin's lymphoma, ofatumumab … [L12753] The FDA subsequently approved ofatumumab for the treatment of RMS on August 20, 2020.
Categories: CD20 (Clusters of Differentiation 20) inhibitors, Amino Acids, Peptides, and ProteinsProducts: Jemvy 20 mg/0,4 mL Enjeksiyonluk Çözelti İçeren Kullanıma Hazır Kalem, 1 ADET, JEMVY 20 MG/0,4 ML ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR ENJEKTÖR, 1 ADETRopinirole
go.drugbank.com/drugs/DB00268ApprovedInvestigationalRopinirole, also known as _ReQuip_, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label], [A174547]. … In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing, therefore increased compliance, and offering a similar side effect profile and efficacy to previous
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProducts: ROPINIROL-NEURAX 5 MG, ROPINIROL AL 5 MG FILMTABLTrastuzumab emtansine
go.drugbank.com/drugs/DB05773ApprovedInvestigationalT-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-microtubule agent, DM1 (a maytansine derivative)--to produce cell cycle arrest and apoptosis. … Second that there is a black box warning of serious side effects such as hepatotoxicity, embryo-fetal toxicity, and cardiac toxicity.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsSynonyms: T-DM1Vilazodone
go.drugbank.com/drugs/DB06684ApprovedInvestigationalVilazodone is a novel compound with combined high affinity and selectivity for the 5-hydroxytryptamine (5-HT) transporter and 5-HT(1A) receptors[Label,A177622]. … Vilazodone may also be associated with less sexual dysfunction and weight gain[A6947]. Vilazodone was given FDA approval on January 21, 2011[L6046,A177622].
Categories: Heterocyclic Compounds, 1-Ring, Serotonin 5-HT1 Receptor AgonistsProducts: ZİLADONE 10 MG FİLM KAPLI TABLET, 30 ADET, ZİLADONE 20 MG FİLM KAPLI TABLET, 30 ADETTelmisartan
go.drugbank.com/drugs/DB00966ApprovedInvestigationalGenerally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular … smooth muscle, ultimately leading to a reduction in arterial blood pressure.
Mixtures: XIFEN A®80 /10 MG, XIFEN A ®80 /5 MGCategories: Angiotensin II Type 1 Receptor Blockers, telmisartan and diuretics