Vilazodone is an antidepressant agent used for the treatment of major depressive disorder that targets the 5-HT transporter and 5-HT1A receptors. Vilazodone is a novel compound with combined high affinity and selectivity for the 5-hydroxytryptamine (5-HT) transporter and 5-HT(1A) receptors.
- Mechanism
- Curator reviewed · 1 reference
Vilazodone selectively inhibits serotonin reuptake in the central nervous system as well as acting as a partial agonist of 5HT-1A receptors. The exact mechanism for how these effects translate to its antidepressant effects are not known, though there is an association between these effects and antidepressive activity.
- Primary indication
- Vilazodone is approved for treatment of major depressive disorder.Curator reviewed · 1 structured indication
- Formula / weight
- C26H27N5O2 · 441.5249 g/mol (avg)
- First approval
- Canada, 2015 · United States, 2011
- Code names
- EMD-515259 · EMD-68843 · SB 659746A
- Brand names
Resolves to
SGEGOXDYSFKCPT-UHFFFAOYSA-NSMILESNC(=O)C1=CC2=CC(=CC=C2O1)N1CCN(CCCCC2=CNC3=C2C=C(C=C3)C#N)CC1What you can answer from here — as of September 23, 2026
Which drugs share a target with Vilazodone, and which of those have an active Phase 3 trial?
Create a free account or log in to explore the full data card.
Create Account