Search

Adefovir dipivoxil

It is ineffective against HIV-1. Adefovir dipivoxil is the diester prodrug of adefovir. … Adefovir dipivoxil, previously called bis-POM PMEA, with trade names Preveon and Hepsera, is an orally-administered acyclic nucleotide analog reverse transcriptase inhibitor (ntRTI) used for treatment

Metharbital

Metharbital is a barbiturate anticonvulsant, similar to phenobarbital, marketed as Gemonil by Abbott Laboratories. It was patented in 1905 by Emil Fischer of Merck.

Roflumilast

Roflumilast is a highly selective phosphodiesterase-4 (PDE4) inhibitor. … [A251385] PDE4 is a major cyclic-3',5′-adenosinemonophosphate (cyclic AMP, cAMP)-metabolizing enzyme [L37564] expressed on nearly all immune and pro-inflammatory cells, in addition to structural cells

Pyruvic acid

An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures.

Drotrecogin alfa

Drotrecogin alfa was withdrawn from the market after a major study indicated that it was not effective in improving outcomes in patients with sepsis. … It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond.

Mafenide

Mafenide is a sulfonamide-type antimicrobial agent used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns. … [L36773] In 1998, mafenide acetate was approved under the FDA’s accelerated approval regulations.

Eravacycline

Eravacycline, known as _Xerava_ by Tetraphase Pharmaceuticals, is a fully synthetic fluorocycline antibiotic of the tetracycline class with activity against clinically significant gram-negative, gram-positive … It was first approved by the FDA on August 27, 2018 [L4540].

(S)-camphor

Camphor is a major active ingredient in over-the-counter balms and liniments supplied as topical analgesics by causing sensitization to heat and coolness to relieve minor muscle and joint pain [A33086] … (S)-camphor, or L(-)-Camphor, is a stereoisomer of [DB01744], a bicyclic monoterpene known to potentiate both heat and cold sensations [A33087].

Magnesium ascorbate

Tovorafenib

Tovorafenib is a selective type II RAF kinase inhibitor with anti-tumour activity. … [L50587] BRAF oncogenic mutations in cancers drive dysregulated cell growth, proliferation, and differentiation.