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Displaying results 3091 - 3100 of 10000 in total
  1. Target

    Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

    go.drugbank.com/bio_entities/BE0009517
    TargetHumans

    Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration (PubMed:26774281).

    Polypeptides: Phosphatidylinositol 5-phosphate 4-kinase type-2 betaSynonyms: PI(5)P 4-kinase type II beta, PtdIns(5)P-4-kinase isoform 2-beta
  2. Target

    Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

    go.drugbank.com/bio_entities/BE0009518
    TargetHumans

    Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity.

    Polypeptides: Phosphatidylinositol 5-phosphate 4-kinase type-2 gammaSynonyms: PI(5)P 4-kinase type II gamma, Phosphatidylinositol 5-phosphate 4-kinase type II gamma
  3. Target

    cAMP-specific 3',5'-cyclic phosphodiesterase 4 (PDE4)

    go.drugbank.com/bio_entities/BE0009963
    TargetHumans

    Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes

    Polypeptides: 3',5'-cyclic-AMP phosphodiesterase 4A, 3',5'-cyclic-AMP phosphodiesterase 4BFunction: 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-AMP phosphodiesterase activity
  4. Drug

    Ferric hydroxide

    go.drugbank.com/drugs/DB13423
    Investigational

    Products: FERIFER 100 MG/5 ML ORAL COZELTI ICEREN 10 KASIK, FERIFER 100 MG/5 ML ORAL COZELTI ICEREN 30 KASIK
  5. Drug

    Manidipine

    go.drugbank.com/drugs/DB09238
    ApprovedInvestigationalWithdrawn

    Manidipine (INN) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive. … It is selective for vasculature and does not produce effects on the heart at clinically relevant dosages.

    Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingProducts: MANIDIPINA EG, IPERTEN 20 MG TABLET, 28 ADET
  6. Drug

    Oxymorphone

    go.drugbank.com/drugs/DB01192
    ApprovedVet approved

    On June 8, 2017, FDA requested Endo Pharmaceuticals to remove the medication from the market due to opioid misuse and abuse risks associated with the product's injectable reformulation. … It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092).

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: Opana ER, Numorphan Injection 1.5mg/ml
  7. Drug

    Rilpivirine

    go.drugbank.com/drugs/DB08864
    ApprovedInvestigational

    Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients.[A31328] It is a diarylpyrimidine derivative. … [L1030] On November 21, 2017, Rilpivirine, in combination with [dolutegravir], was approved as part of the first complete treatment regimen with only two drugs for the treatment of adults with HIV-1 named

    Mixtures: ODEFSEY® 200 MG - 25 MG - 25 MG TABLETAS RECUBIERTAS, ODEFSEY 200 MG/25 MG/25 MG FİLM KAPLI TABLET, 90 ADETCategories: Antivirals used in combination for the treatment of HIV infections, P-glycoprotein inhibitors
  8. Drug

    Allopurinol

    go.drugbank.com/drugs/DB00437
    ApprovedInvestigational

    Gout is a disease that occurs by the deposition of monosodium urate crystals (MSU) in body tissues, especially around joints [A175942]. … Allopurinol is a xanthine oxidase enzyme inhibitor that is considered to be one of the most effective drugs used to decrease urate levels and is frequently used in the treatment of chronic gout [A36705

    Categories: Cytochrome P-450 CYP1A2 Inhibitors, Heterocyclic Compounds, 2-RingSynonyms: 1H-Pyrazolo(3,4-d)pyrimidin-4-ol, 4-Hydroxypyrazolo(3,4-d)pyrimidine
  9. Drug

    Semaglutide

    go.drugbank.com/drugs/DB13928
    ApprovedInvestigational

    [L46726] On August 15, 2025, the FDA granted Accelerated Approval for the treatment of metabolic-associated steatohepatitis (MASH) in adults with moderate-to-advanced fibrosis [L53901] … [L41335] On May 31, 2023, the FDA issued a warning regarding the use of compounded semaglutide after receiving adverse event reports.

    Categories: Drugs Used in Diabetes, Glucagon-like peptide-1 (GLP-1) analoguesProducts: Wegovy® 1 mg/0.5 mL (1 mg/dose) Solution for injection in pre-filled pen, Ozempic® 1.34 mg/ml (1 mg/dose) Solution for injection in pre-filled pen
  10. Drug

    Levomethadone

    go.drugbank.com/drugs/DB13515
    Investigational

    Categories: Drugs Used in Opioid Dependence, Drugs Used in Addictive DisordersSynonyms: l-methadone