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Duloxetine
go.drugbank.com/drugs/DB00476ApprovedInvestigationalDuloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. … Duloxetine continues to be investigated for the treatment of pain in cancer, surgery, and more.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSynonyms: (3S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine, (S)-duloxetineBortezomib
go.drugbank.com/drugs/DB00188ApprovedInvestigational[A204083] The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest and … [A204146] Phase I, II, III, and IV clinical trials are undergoing to investigate the therapeutic efficacy of bortezomib in leukemia, myasthenia gravis, systemic lupus erythematosus, rheumatoid arthritis
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexSynonyms: N-[(1R)-1-(DIHYDROXYBORYL)-3-methylbutyl]-N-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide, [(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acidBromazepam
go.drugbank.com/drugs/DB01558ApprovedIllicitOne of the benzodiazepines that is used in the treatment of anxiety disorders. It is a Schedule IV drug in the U.S. and Canada and under the Convention on Psychotropic Substances. … It is a intermediate-acting benzodiazepine.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingProducts: BROMAZEPAM EG, BROMAZEPAM N&POmega-3-acid ethyl esters
go.drugbank.com/drugs/DB09539ApprovedInvestigationaltriglyceride levels in adults with severe (≥ 500 mg/dL) hypertriglyceridemia[FDA Label][A176687]. … Omega-3-acid ethyl esters are currently marketed in the US, EU, and many other regions under the brand name Lovaza[FDA Label][L5849].
Synonyms: omega-3 acid ethyl esters, Omega-3-acid ethyl estersMixtures: Mi-Omega NF, ROSUVASTATINA E OMEGA 3 SPA SOCIET PRODOTTI ANTIBIOTICIDipyridamole
go.drugbank.com/drugs/DB00975ApprovedInvestigationalA phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin.
Mixtures: Aspirin and Extended - Release Dipyridamole Capsules, 25 mg / 200 mg, Aspirin and Extended - Release Dipyridamole Capsules, 25 mg / 200 mgCategories: Phosphodiesterase 5 Inhibitors, P-glycoprotein inhibitorsGanciclovir
go.drugbank.com/drugs/DB01004ApprovedInvestigationalAn acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
Categories: MATE 1 Substrates, MATE 2 SubstratesSynonyms: 2-(6-Amino-purin-9-ylmethoxy)-propane-1,3-diol, 2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-1H-purin-6(9H)-oneProthrombin
go.drugbank.com/drugs/DB11311ApprovedInvestigationalProthrombin Complex Concentrate (Human), is indicated for the urgent reversal of acquired coagulation factor deficiency induced by Vitamin K antagonist (VKA, e.g., warfarin) therapy in adult patients with
Mixtures: COFACT 250 IU/10 ML IV ENJEKSIYON IÇIN TOZ IÇEREN FLAKON, 1 ADET, COFACT 500 IU/20 ML IV ENJEKSIYON IÇIN TOZ IÇEREN FLAKON, 1 ADETBetahistine
go.drugbank.com/drugs/DB06698ApprovedInvestigational[A220333,L16403] Betahistine was first approved by the FDA in the 1970s but withdrawn within approximately 5 years due to a lack of evidence supporting its efficacy. … It has a significant impact on both the physical and social functioning of affected individuals.
Categories: Heterocyclic Compounds, 1-RingSynonyms: N-methyl-2-(2-pyridinyl)ethanamine, N-methyl-2-pyridineethanamineDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
go.drugbank.com/bio_entities/BE0003558TargetHumansCatalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (PubMed:10725373, PubMed:10906126, PubMed:11050148)
Polypeptides: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11AFunction: 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activityNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
go.drugbank.com/bio_entities/BE0000243TargetHumansAccessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The ...
Polypeptides: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial