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Procyclidine
go.drugbank.com/drugs/DB00387ApprovedInvestigationalA muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism.
Propafenone
go.drugbank.com/drugs/DB01182ApprovedInvestigationalAn antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesQuazepam
go.drugbank.com/drugs/DB01589ApprovedIllicit[L44913] It appears to be unique amongst other benzodiazepine derivatives in its relatively high affinity for sleep-promoting α1 subunit-containing GABA<sub>A</sub> receptors and low affinity for other … It was first approved in the US in 1985 and is used as a hypnotic for the treatment of insomnia.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InhibitorsBisoxatin
go.drugbank.com/drugs/DB09219ApprovedIt is marketed in Belgium under the tradename Wylaxine and used for the treatment of constipation and for preparation of the colon for surgical procedures.
Categories: Drugs for ConstipationEzogabine
go.drugbank.com/drugs/DB04953ApprovedWithdrawnIt is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures
Synonyms: Ethyl 2-amino-4-((p-fluorobenzyl)amino)carbanilateSpiramycin
go.drugbank.com/drugs/DB06145ApprovedInvestigationalWithdrawnSpiramycin is a primarily bacteriostatic macrolide antimicrobial agent with activity against Gram-positive cocci and rods, Gram-negative cocci and also Legionellae, mycoplasmas, chlamydiae, some types of spirochetes, Toxoplasma gondii an...
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UsePentostatin
go.drugbank.com/drugs/DB00552ApprovedInvestigationalThe drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia.
Vardenafil
go.drugbank.com/drugs/DB00862ApprovedVardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction. … Compared to [sildenafil] and [tadalafil], vardenafil is a more potent inhibitor of PDE5; however, its selectivity for other PDE isoforms is lower than the one detected for tadalafil.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesG protein-coupled receptor family C group 5 member D
go.drugbank.com/bio_entities/BE0010290TargetHumansG protein-coupled receptor involved in hard keratin expression and likely plays a role in the development of hair and nails
Polypeptides: G protein-coupled receptor family C group 5 member DFunction: G protein-coupled receptor activityTriclocarban
go.drugbank.com/drugs/DB11155ApprovedTriclocarban, with the chemical formula C13H9Cl3N2O [L2675] is an antibacterial agent that is particularly effective against Gram-positive bacteria such as *Staphylococcus aureus*.